ArticleInternational journal of obesity (2005)2013
Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.
Article in International journal of obesity (2005), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02829619 (Meal Timing, Genetics and Weight Loss in a Mediterranean Population), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meal Timing, Genetics and Weight Loss in a Mediterranean Population
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Pooled it
- Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study.Clinical nutrition (Edinburgh, Scotland) · 2018Trial
- Comparing Human-Smartphone Interactions and Actigraphy Measurements for Circadian Rhythm Stability and Adiposity: Algorithm Development and Validation Study.Journal of medical Internet research · 2024Article
- Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents.Frontiers in public health · 2024Article
- Sex-dependent relationship of polymorphisms in CLOCK and REV-ERBα genes with body mass index and lipid levels in children.Scientific reports · 2023Article
- Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness.Annals of translational medicine · 2023Review
- Review
- Chronodisruption and Ambulatory Circadian Monitoring in Cancer Patients: Beyond the Body Clock.Current oncology reports · 2022Review
- Rest-Activity Rhythm Is Associated With Obesity Phenotypes: A Cross-Sectional Analysis.Frontiers in endocrinology · 2022Article
- Nonalcoholic Fatty Liver Disease (NAFLD) Name Change: Requiem or Reveille?Journal of clinical and translational hepatology · 2021Review
- Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration.The Journal of clinical endocrinology and metabolism · 2020Article
- Article
- The Impact of the Circadian GenesJournal of clinical medicine · 2020Article
- Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease.Frontiers in physiology · 2019Review
- The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects.Endocrine reviews · 2018Review
- CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control.International journal of obesity (2005) · 2018Article
- Circadian Rhythmic Characteristics in Men With Substance Use Disorder Under Treatment. Influence of Age of Onset of Substance Use and Duration of Abstinence.Frontiers in psychiatry · 2018Article
- Actigraphy-Derived Daily Rest-Activity Patterns and Body Mass Index in Community-Dwelling Adults.Sleep · 2017Article
- Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C.International journal of obesity (2005) · 2016Observational
- Circadian rhythms of liver physiology and disease: experimental and clinical evidence.Nature reviews. Gastroenterology & hepatology · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionGenetics is behind our circadian machinery. CLOCK (Circadian Locomotor Output Cycles Kaput) 3111T/C single-nucleotide polymorphism (SNP) has been previously related to obesity and weight loss. However, phenotypic association and functionality of CLOCK 3111 locus is still unknown. The aim of this study was to determine, in free-living conditions, if the presence of CLOCK 3111C in overweight women could be related to (a) circadian disorders, and (b) changes in sleep quality, to improve understanding of the previously demonstrated associations with obesity and reduced weight loss of the C carriers.
methodsWrist temperature, actimetry and position (TAP) and TAP variables were measured as markers of circadian functionality during 8 consecutive days. A rest-activity and food diary was also completed, whereas sleep quality was determined by domiciliary polysomnography. We recruited 85 women who were overweight with body mass index (BMI) of 28.59±4.30 kg m(-2) and age 43±12 years. From this sample, we found that 43 women were carrying the minor allele (C) for CLOCK 3111T/C SNP and 42 women were TT carriers (major allele carriers). Both groups of patients were matched for number, age, obesity parameters and energy intake.
resultsCompared with TT subjects, who showed more robust circadian rhythm profiles, patients with the C allele displayed significant circadian abnormalities: lower amplitude and greater fragmentation of the rhythm, a less stable circadian pattern and a significantly weakened circadian function, as assessed by the circadian function index (CFI). C subjects were also less active, started their activities later in the morning and were sleepier during the day, showing a delayed acrophase that characterizes 'evening-type' subjects.
conclusionC genetic variants in CLOCK 3111T/C display a less robust circadian rhythm than TT and a delayed acrophase that characterizes 'evening-type' subjects. We support the notion that identifying CLOCK genotypes in patients may assist the therapist in characterization of the roots of the metabolic problem.
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