ArticleEndocrinology2013
Activation of membrane-associated estrogen receptors decreases food and water intake in ovariectomized rats.
Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- A microstructural analysis of sodium and water intake in male and female rats.Physiology & behavior · 2026Article
- Drinking microstructure analysis of direct controls of water intake in male and female rats.Physiology & behavior · 2026Article
- Sex- and site-specific effects of GPER-1 activation on saccharin vs cocaine preference in male and female rats.Hormones and behavior · 2025Article
- Fluid transitions.Neuropharmacology · 2024Review
- 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.Science advances · 2024Article
- Bidirectional effects of estradiol on the control of water intake in female rats.Hormones and behavior · 2021Article
- The anti-dipsogenic and anti-natriorexigenic effects of estradiol, but not the anti-pressor effect, are lost in aged female rats.Physiological reports · 2021Article
- Organophosphate Flame Retardants Excite Arcuate Melanocortin Circuitry and Increase Neuronal Sensitivity to Ghrelin in Adult Mice.Endocrinology · 2020Article
- The Disruptive Effects of Estrogen Removal before Puberty on Risk for Binge Eating in Female Rats.Clinical psychological science : a journal of the Association for Psychological Science · 2020Article
- The interactions of diet-induced obesity and organophosphate flame retardant exposure on energy homeostasis in adult male and female mice.Journal of toxicology and environmental health. Part A · 2020Article
- Anorexigenic effects of estradiol in the medial preoptic area occur through membrane-associated estrogen receptors and metabotropic glutamate receptors.Hormones and behavior · 2019Article
- Selective activation of estrogen receptors, ERα and GPER-1, rapidly decreases food intake in female rats.Hormones and behavior · 2018Article
- Sex Differences in the Behavioral Desensitization of Water Intake Observed After Repeated Central Injections of Angiotensin II.Endocrinology · 2018Article
- RFamide-related Peptide-3 and the Trade-off between Reproductive and Ingestive Behavior.Integrative and comparative biology · 2017Article
- Article
- Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- Divergent effects of ERα and ERβ on fluid intake by female rats are not dependent on concomitant changes in AT1R expression or body weight.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Multiple estrogen receptor subtypes influence ingestive behavior in female rodents.Physiology & behavior · 2015Review
- Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study.Psychological medicine · 2015Article
- Activation of G protein-coupled estrogen receptor 1 (GPER-1) decreases fluid intake in female rats.Hormones and behavior · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Estradiol (E2) decreases food and water intake in a variety of species, including rats. Available evidence suggests that this is mediated by genomic mechanisms that are most often attributed to nuclear estrogen receptors. More recent studies indicate that membrane-associated estrogen receptors (mERs) also can influence gene expression through the activation of transcription factors, yet it is unclear whether mERs are involved in mediating the hypophagic and antidipsetic effects of E2. In the present experiments, we injected E2 or a membrane-impermeable form of E2 (E2-BSA) into the lateral cerebral ventricle of ovariectomized female rats and evaluated the effect on 23 h food and water intake. First, we found that higher doses of E2 were necessary to reduce water intake than were sufficient to reduce food intake. Analysis of drinking microstructure revealed that the decrease in water intake after E2 treatment was mediated by both a decrease in burst number and burst size. Next, the activation of mERs with E2-BSA decreased both overnight food and water intake and analysis of drinking microstructure indicated that the decreased water intake resulted from a decrease in burst number. Finally, E2-BSA did not condition a taste aversion, suggesting that the inhibitory effects on food and water intake were not secondary to malaise. Together these findings suggest that activation of mERs is sufficient to decrease food and water intake in female rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.