ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2013
Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Effects of muscle vibration on multi-finger interaction and coordination.Experimental brain research · 2013Trial
- Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration.bioRxiv : the preprint server for biology · 2026Article
- Changes in synergy formation and modulation during cyclic finger force production tasks in female adults with dystonic cerebral palsy.Experimental brain research · 2026Article
- Functional changes in spinal circuitry in essential tremor revealed with analysis of intramuscle synergies.Journal of neurophysiology · 2026Article
- Carpal tunnel release surgery restores force control but not force coordination in CTS patients.Scientific reports · 2025Article
- Two aspects of feed-forward control of action stability: effects of action speed and unexpected events.Experimental brain research · 2024Article
- Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing.Neurotoxicology · 2022Article
- Higher visual gain contributions to bilateral motor synergies and force control.Scientific reports · 2022Article
- Unintentional force drifts across the human fingers: implications for the neural control of finger tasks.Experimental brain research · 2022Article
- Recent Advances in the Neural Control of Movements: Lessons for Functional Recovery.Physical therapy research · 2022Review
- One more time about motor (and non-motor) synergies.Experimental brain research · 2021Review
- Stability of Action and Kinesthetic Perception in Parkinson's Disease.Journal of human kinetics · 2021Article
- Synergic control of action in levodopa-naïve Parkinson's disease patients: I. Multi-finger interaction and coordination.Experimental brain research · 2020Article
- Effects of spastic cerebral palsy on multi-finger coordination during isometric force production tasks.Experimental brain research · 2019Article
- Quantitative analysis of multi-element synergy stabilizing performance: comparison of three methods with respect to their use in clinical studies.Experimental brain research · 2019Article
- Muscle coactivation: definitions, mechanisms, and functions.Journal of neurophysiology · 2018Review
- Systemic effects of deep brain stimulation on synergic control in Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Multi-Finger Interaction and Synergies in Finger Flexion and Extension Force Production.Frontiers in human neuroscience · 2017Article
- Article
- Towards physics of neural processes and behavior.Neuroscience and biobehavioral reviews · 2016Review
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Authors and funding
4 authors.
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Abstract
objectivesWe investigated changes in finger interaction and coordination in patients with olivo-ponto-cerebellar atrophy (OPCA) using the recently developed approach to motor synergies based on the principle of motor abundance.
methodsOPCA patients and control subjects performed sets of maximal and submaximal force production tasks by the fingers of each of the hands. Indices of multi-finger synergies were quantified within the framework of the uncontrolled manifold hypothesis.
resultsThe patients showed lower maximal forces, higher indices of finger interdependence (enslaving), and lower indices of multi-finger synergies stabilizing total force in four-finger tasks. In addition, the patients showed an impaired ability to adjust synergies in preparation to a quick action (small and delayed anticipatory synergy adjustments). The synergy indices showed significant correlations with the clinical scores (both UPDRS total motor scores and ataxia related sub-scores). The observed changes in the indices of finger interaction and coordination were qualitatively similar to those reported earlier for patients with Parkinson's disease; however, the magnitude of the changes was much higher in the OPCA group.
conclusionsThese findings fit the hypotheses on the role of the cerebellum in assembling motor synergies and in the feed-forward control of action. They suggest that the synergy index measured in artificial, constrained laboratory tasks may be predictive of more general changes in motor behavior. SIGNIFICANCE: The results suggest that studies of multi-digit synergies may be particularly sensitive to subcortical disorders and may provide a much-needed tool for quantitative assessment of impaired coordination in such patients.
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