Evidence map›Paper›PMID 23182559›Full record

ReviewObstetrics and gynecology clinics of North America2012

Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility.

Matthew Latham Macer, Hugh S Taylor

Open access · greenAbstract readReview
In one paragraph

Review in Obstetrics and gynecology clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 281 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 11 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 11 syntheses or guidelines pooled it, 660 citations in OpenAlex.

  1. Clinical practice guideline "preconception care".Archives of gynecology and obstetrics · 2026
    Guideline
  2. Pooled it
  3. Pooled it
  4. Chronic Endometritis and Endometriosis: Two Sides of the Same Coin?Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
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  8. Expression ofInternational journal of molecular sciences · 2023
    Pooled it
  9. Gonadotropin-releasing hormone analogues for endometriosis.The Cochrane database of systematic reviews · 2023
    Pooled it
  10. Pooled it
  11. Pre- and postsurgical medical therapy for endometriosis surgery.The Cochrane database of systematic reviews · 2020
    Pooled it
  12. Trial
  13. Trial
  14. Review
  15. Review
  16. Article
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  20. Article

221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew Latham MacerDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, PO Box 208063, New Haven, CT 06520-8063, USA.
Hugh S Taylor
Yale University · US

Funding

Tissue Factor and EmdometriosisU54HD052668 · NICHD · YALE UNIVERSITY · PI TAYLOR, HUGH SMITH · 2007 to 2011
$6.6M
Environmental Estrogen Induced Epigenetic Alteration of Uterine Stem CellsR01HD076422 · NICHD · YALE UNIVERSITY · PI TAYLOR, HUGH SMITH · 2012 to 2016
$2.0M
Hox Gene Expression in Human EndometriumR01HD036887 · NICHD · YALE UNIVERSITY · PI TAYLOR, HUGH S · 2003 to 2007
$1.4M
NICHD NIH HHS R01 HD036887NICHD NIH HHS R01 HD076422NICHD NIH HHS U54 HD052668
6 · The paper itself

Abstract

Endometriois has been associated with infertility; however, the mechanisms by which it affects fertility are still not fully understood. This article reviews the proposed mechanisms of endometriosis pathogenesis, its effects on fertility, and treatments of endometriosis-associated infertility. Theories on the cause of the disease include retrograde menstruation, coelomic metaplasia, altered immunity, stem cells, and genetics. Endometriosis affects gametes and embryos, the fallopian tubes and embryo transport, and the eutopic endometrium; these abnormalities likely all impact fertility. Current treatment options of endometriosis-associated infertility include surgery, superovulation with intrauterine insemination, and in vitro fertilization. We also discuss potential future treatments for endometriosis-related infertility.

Indexed as

Reproductive Techniques, AssistedEndometriosisFemaleFertilization in VitroHumansInfertility, FemaleInsemination, ArtificialPelvic PainPrecision MedicinePregnancySuperovulation

Identifiers

PMID23182559
PMCPMC3538128
OpenAlexW1788063486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.