Evidence map›Paper›PMID 23182478›Full record

ReviewBlood reviews2013

Genetics of graft-versus-host disease: the major histocompatibility complex.

Effie W Petersdorf

Open access · greenAbstract readReview
In one paragraph

Review in Blood reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Macrophage regulation of graft-World journal of clinical cases · 2020
    Review
  14. Article
  15. Policy Challenges for Organ Allocation in an Era of "Precision Medicine".Canadian journal of kidney health and disease · 2020
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 2 countries.

Effie W PetersdorfDivision of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States. epetersd@fhcrc.org
Fred Hutch Cancer Center · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Geoffrey Roger HILL · 1985 to 2026
$128.4M
Hematopopietic Stem Cell TransplantationU01AI069197 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Effie W Petersdorf · 2005 to 2026
$18.9M
Clinical Significance of MHC Haplotypes in Hematopoietic Cell TransplantationR01CA100019 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERSDORF, EFFIE W · 2003 to 2025
$9.1M
Genetic Mechanisms of Survivorship Disparities after Unrelated HCTU01CA162194 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERSDORF, EFFIE W · 2011 to 2015
$1.7M
NCI NIH HHS CA100019NCI NIH HHS CA162194NCI NIH HHS CA18029NCI NIH HHS P01 CA018029NCI NIH HHS R01 CA100019NCI NIH HHS U01 CA162194NIAID NIH HHS AI069197NIAID NIH HHS U01 AI069197
6 · The paper itself

Abstract

Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6. Among the hundreds of genes located within the MHC region, the best known and characterized are the classical HLA genes, HLA-A, C, B, DRB1, DQB1, and DPB1. They play a fundamental role in T cell immune responses, and HLA-A, C, and B also function as ligands for the natural killer cell immunoglobulin-like receptors involved in innate immunity. This review highlights the state-of-the art in the field of histocompatibility and immunogenetics of the MHC with respect to genetic risk factors for GVHD.

Indexed as

Major Histocompatibility ComplexCytokinesGene ExpressionGraft vs Host DiseaseHaplotypesHematopoietic Stem Cell TransplantationHistocompatibilityHistocompatibility TestingHLA AntigensHumansKiller Cells, NaturalReceptors, KIRSignal TransductionT-LymphocytesTransplantation, HomologousCytokinesHLA AntigensReceptors, KIR

Identifiers

PMID23182478
PMCPMC3626414
OpenAlexW2064956449

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.