ArticleJournal of psychiatry & neuroscience : JPN2013
Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?
Article in Journal of psychiatry & neuroscience : JPN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Adaptogenic-Like Potential of Bauhinia forficata Leaf Extracts: Behavioral and Oxidative Outcomes in an Acute Stress Mouse Model.Brain and behavior · 2026Article
- Long-term social isolation during adolescence exacerbated cardiac dysfunction after myocardial infarction.Translational psychiatry · 2026Article
- Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation.Brain sciences · 2025Article
- Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions.Nature communications · 2025Article
- Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation.Journal of visualized experiments : JoVE · 2025Article
- Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.bioRxiv : the preprint server for biology · 2024Article
- Trait sensitivity to stress and cognitive bias processes in fish: A brief overview.Personality neuroscience · 2024Review
- Effects of maternal social isolation on adult rodent offspring cognition.Scientific reports · 2023Article
- Homeostatic Regulation of Energetic Arousal During Acute Social Isolation: Evidence From the Lab and the Field.Psychological science · 2023Article
- Article
- DNA Damage and Radiosensitivity in Blood Cells from Subjects Undergoing 45 Days of Isolation and Confinement: An Explorative Study.Current issues in molecular biology · 2022Article
- Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals.Neuroscience and behavioral physiology · 2022Article
- Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system.Psychoneuroendocrinology · 2022Review
- Sex-Specific Social Effects on Depression-Related Behavioral Phenotypes in Mice.Life (Basel, Switzerland) · 2021Article
- Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise.Social neuroscience · 2021Article
- The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation.Cell · 2021Review
- Article
- Examining the central effects of chronic stressful social isolation on rats.Biomedical reports · 2020Article
- Emotion in animal contests.Proceedings. Biological sciences · 2020Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough mood-congruent memory (MCM), or the tendency to recall information consistent with one's mood, is a robust phenomenon in human depression, to our knowledge, it has never been demonstrated in animals.
methodsMice were subjected to social isolation (SI) or crowding for 12 hours and had their depressive-like behaviour (evaluated by the forced swim, tail suspension, sucrose preference and splash tests) or their serum corticosterone concentrations evaluated. In addition, we determined the temporal forgetting curve of the plus-maze discriminative avoidance task (PM-DAT) and examined the effects of SI or crowding on memory retrieval in the PM-DAT. Finally, we verified the effects of metyrapone pretreatment on reinstatement of memory retrieval or on the increase of corticosterone levels induced by SI.
resultsTwelve hours of SI produced depressive-like behaviour, enhanced corticosterone concentration and reinstated retrieval of a forgotten discriminative aversive (i.e., negatively valenced) task. Depressive-like behaviour was critical for this facilitative effect of SI because 12 hours of crowding neither induced depressive-like behaviour nor enhanced retrieval, although it increased corticosterone levels at the same magnitude as SI. However, corticosterone increase was a necessary condition for MCM in mice, in that the corticosterone synthesis inhibitor metyrapone abolished SI-induced retrieval reinstatement. LIMITATIONS: Our study did not investigate the effects of the social manipulations proposed here in a positively valenced task.
conclusionTo our knowledge, the present paper provides the first evidence of MCM in animal models.
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