ArticleThe journal of pain2012
Sex differences in exercise-induced muscle pain and muscle damage.
Article in The journal of pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The Role of Biomarkers in Monitoring Chronic Fatigue Among Male Professional Team Athletes: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Acute muscle damage responses in elbow flexors following eccentric quasi-isometric exercise.Scientific reports · 2026Trial
- Artepillin C-rich propolis extract supplementation promotes muscle recovery following exercise-induced muscle damage in resistance-trained young females: a randomized, placebo-controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Eccentric and concentric blood flow restriction resistance training on indices of delayed onset muscle soreness in untrained women.European journal of applied physiology · 2019Trial
- Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.Physiological reports · 2019Trial
- The effect of milk on the attenuation of exercise-induced muscle damage in males and females.European journal of applied physiology · 2015Trial
- Urinary N-terminal titin fragment concentration as a non-invasive biomarker of exercise-induced muscle damage in males and females.European journal of applied physiology · 2026Article
- Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.Biology of sport · 2025Article
- Psychophysical changes after total sleep deprivation and experimental muscle pain.Journal of sleep research · 2025Article
- Sex Is Not an Independent Predictor of Exercise-Induced Pain After Adjustment for Performance and Pain Sensitivity.Pain research & management · 2025Article
- Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study.Viruses · 2024Article
- Skeletal muscle myosin heavy chain fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy.Experimental physiology · 2024Article
- Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy.bioRxiv : the preprint server for biology · 2024Article
- Microbiota derived D-malate inhibits skeletal muscle growth and angiogenesis during aging via acetylation of Cyclin A.EMBO reports · 2024Article
- Article
- Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise.Healthcare (Basel, Switzerland) · 2022Article
- Effects of Functional Phenolics Dietary Supplementation on Athletes' Performance and Recovery: A Review.International journal of molecular sciences · 2022Review
- Sex differences in the impact of resistance exercise load on muscle damage: A protocol for a randomised parallel group trial.PloS one · 2022Article
- Physiological Characteristics of Female Soccer Players and Health and Performance Considerations: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2021Review
- Exercise-induced muscle damage: mechanism, assessment and nutritional factors to accelerate recovery.European journal of applied physiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledThere is uncertainty about sex differences in exercise-induced muscle pain and muscle damage due to several methodological weaknesses in the literature. This investigation tested the hypothesis that higher levels of exercise-induced muscle pain and muscle damage indicators would be found in women than men when several methodological improvements were executed in the same study. Participants (N = 33; 42% women) with an average age of 23 years (SD = 2.82) consented to participate. After a familiarization session, participants visited the laboratory before and across 4 days after eccentric exercise was completed to induce arm muscle pain and muscle damage. Our primary outcomes were arm pain ratings and pressure pain thresholds. However, we also measured the following indicators of muscle damage: arm girth; resting elbow extension; isometric elbow flexor strength; myoglobin (Mb); tumor necrosis factor (TNFa); interleukin 1beta (IL1b); and total nitric oxide (NO). Temporary induction of muscle damage was indicated by changes in all outcome measures except TNFa and IL1b. In contrast to our hypotheses, women reported moderately lower and less frequent muscle pain than men. Also, women's arm girth and Mb levels increased moderately less than men's, but the differences were not significant. Few large sex differences were detected. PERSPECTIVE: Lower muscle pain among women than men was detected with corresponding, but nonsignificant sex differences in other muscle damage indicators. Methodological advances may have improved alignment of these results with the nonhuman animal findings. This line of research continues to show exceptions to the generalization that women experience greater pain than men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.