ArticleThe Journal of allergy and clinical immunology2013
Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Fat supplementation of human milk for promoting growth in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Fat supplementation of human milk for promoting growth in preterm infants.The Cochrane database of systematic reviews · 2018Pooled it
- Immunonutrition: Feeding the gut, skin, and immune system.Asia Pacific allergy · 2026Review
- The immune anatomy of the small intestine facilitates regulatory responses.Frontiers in immunology · 2026Review
- Fermented Apple Juice Reduces the Susceptibility of Offspring Mice to Food Allergy Exacerbated by Maternal High-Fat Diet.Nutrients · 2025Article
- Malnutrition and Allergies: Tipping the Immune Balance towards Health.Journal of clinical medicine · 2024Review
- Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity.Frontiers in immunology · 2024Article
- The Role of Diet and Nutrition in Allergic Diseases.Nutrients · 2023Review
- Dietary Linolenic Acid Increases Sensitizing and Eliciting Capacities of Cow's Milk Whey Proteins in BALB/c Mice.Nutrients · 2022Article
- Intestinal Uptake and Tolerance to Food Antigens.Frontiers in immunology · 2022Review
- Triacylglycerides and Phospholipids from Egg Yolk Differently Influence the Immunostimulating Properties of Egg White Proteins.Nutrients · 2021Article
- Enterocytes in Food Hypersensitivity Reactions.Animals : an open access journal from MDPI · 2021Article
- Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes.Frontiers in immunology · 2021Article
- Egg yolk augments type 2 immunity by activating innate cells.European journal of nutrition · 2020Article
- Antigen-Presenting Cells in Food Tolerance and Allergy.Frontiers in immunology · 2020Review
- Recent advances in mechanisms of food allergy and anaphylaxis.F1000Research · 2020Review
- Maternal triacylglycerol signature and risk of food allergy in offspring.The Journal of allergy and clinical immunology · 2019Article
- Palm Oil in Lipid-Based Formulations and Drug Delivery Systems.Biomolecules · 2019Review
- IgE promotes type 2 innate lymphoid cells in murine food allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Experimental Models for Studying Food Allergy.Cellular and molecular gastroenterology and hepatology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe prevalence of peanut allergies is increasing. Peanuts and many other allergen sources contain significant amounts of triglycerides, which affect absorption of antigens but have unknown effects on sensitization and anaphylaxis. We recently reported that dietary medium-chain triglycerides (MCTs), which bypass mesenteric lymph and directly enter portal blood, reduce intestinal antigen absorption into blood compared with long-chain triglycerides (LCTs), which stimulate mesenteric lymph flow and are absorbed in chylomicrons through mesenteric lymph.
objectiveWe sought to test how dietary MCTs affect food allergy.
methodsC3H/HeJ mice were fed peanut butter protein in MCT, LCT (peanut oil), or LCT plus an inhibitor of chylomicron formation (Pluronic L81). Peanut-specific antibodies in plasma, responses of the mice to antigen challenges, and intestinal epithelial cytokine expression were subsequently measured.
resultsMCT suppressed antigen absorption into blood but stimulated absorption into Peyer patches. A single gavage of peanut protein with MCT, as well as prolonged feeding in MCT-based diets, caused spontaneous allergic sensitization. MCT-sensitized mice experienced IgG-dependent anaphylaxis on systemic challenge and IgE-dependent anaphylaxis on oral challenge. MCT feeding stimulated jejunal-epithelial thymic stromal lymphopoietin, Il25, and Il33 expression compared with that seen after LCT feeding and promoted T(H)2 cytokine responses in splenocytes. Moreover, oral challenges of sensitized mice with antigen in MCT significantly aggravated anaphylaxis compared with challenges with the LCT. Importantly, the effects of MCTs could be mimicked by adding Pluronic L81 to LCTs, and in vitro assays indicated that chylomicrons prevent basophil activation.
conclusionDietary MCTs promote allergic sensitization and anaphylaxis by affecting antigen absorption and availability and by stimulating T(H)2 responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.