ArticleThe Journal of allergy and clinical immunology2013
DJ-1 regulates mast cell activation and IgE-mediated allergic responses.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Inhibition of DJ-1 protects from lupus onset and severity.Scientific reports · 2025Article
- Gut microbiota facilitate chronic spontaneous urticaria.Nature communications · 2024Article
- Genome-wide identification of dysregulated alternative splicing and RNA-binding proteins involved in atopic dermatitis.Frontiers in genetics · 2024Article
- Emergent Inflammatory Markers and Echocardiographic Indices in Patients with Bronchial Asthma.Biomolecules · 2023Article
- Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated fromMarine drugs · 2022Article
- Anti-Allergic Effects ofAntioxidants (Basel, Switzerland) · 2021Article
- Immunomodulatory role of Parkinson's disease 7 in inflammatory bowel disease.Scientific reports · 2021Article
- Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology.Molecules (Basel, Switzerland) · 2021Review
- Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis.Journal of translational medicine · 2021Article
- Role of DJ-1 in Immune and Inflammatory Diseases.Frontiers in immunology · 2020Review
- Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells.International journal of molecular sciences · 2019Article
- Raf kinase inhibitor protein negatively regulates FcεRI-mediated mast cell activation and allergic response.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells.The Journal of allergy and clinical immunology · 2018Article
- DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.Nature communications · 2017Article
- Recent developments in the role of reactive oxygen species in allergic asthma.Journal of thoracic disease · 2017Review
- Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.PloS one · 2016Article
- High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients.Cancer science · 2015Article
- Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity.BMC complementary and alternative medicine · 2015Article
- Evidence of inflammatory system involvement in Parkinson's disease.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundDJ-1 is an antioxidant protein known to reduce levels of reactive oxygen species (ROS), but its presence or function in mast cells and allergic diseases is unknown.
objectivesWe sought to determine the role and mechanism of DJ-1 in allergic responses in vitro and in vivo.
methodsROS and DJ-1 levels in serum or culture medium were measured with ELISA kits. The role of DJ-1 was evaluated in mast cell cultures and passive cutaneous anaphylaxis in normal or DJ-1 knockout (KO) mice. The mechanism of DJ-1 action was examined by using immunoblotting, immunoprecipitation, RT-PCR, and other molecular biological approaches.
resultsPatients with atopic dermatitis had increased levels of ROS and diminished levels of DJ-1. DJ-1 KO mice exhibited enhanced passive cutaneous anaphylaxis and augmented ROS levels in sera and bone marrow-derived mast cells (BMMCs). Furthermore, antigen-induced degranulation and production of TNF-α and IL-4 were significantly amplified in DJ-1 KO and anti-DJ-1 small interfering RNA-transfected BMMCs compared with that seen in wild-type (WT) BMMCs. Studies with these cells and BMMCs transfected with small interfering RNAs against the phosphatases Src homology domain 2-containing protein tyrosine phosphatase (SHP) 1 and SHP-2 revealed that the DJ-1 KO phenotype could be attributed to suppression of SHP-1 activity and enhancement of SHP-2 activity, leading to strengthened signaling through linker for activation of T cells, phospholipase Cγ, and mitogen-activated protein kinases.
conclusionsA deficiency or constitutive activation of DJ-1 can have implications in mast cell-driven allergic diseases, such as asthma and anaphylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.