ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2012
FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- The FcRn from gene to protein and function: comparison between species.Frontiers in immunology · 2025Review
- Circulating extracellular vesicles in sera of chronic patients as a method for determining active parasitism in Chagas disease.PLoS neglected tropical diseases · 2024Article
- Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance.Frontiers in immunology · 2020Review
- The Neonatal Fc Receptor (FcRn): A Misnomer?Frontiers in immunology · 2019Review
- Regulation of IgE activity in inhalational tolerance via formation of IgG anti-IgE/IgE immune complexes.Clinical and molecular allergy : CMA · 2018Article
- Maternal Immunization: New Perspectives on Its Application Against Non-Infectious Related Diseases in Newborns.Vaccines · 2017Review
- Article
- Clinically significant anti-KEL RBC alloantibodies are transferred by breast milk in a murine model.Vox sanguinis · 2016Article
- Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Enhanced in vitro transcytosis of simian immunodeficiency virus mediated by vaccine-induced antibody predicts transmitted/founder strain number after rectal challenge.The Journal of infectious diseases · 2015Article
- Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies.Methods (San Diego, Calif.) · 2014Article
- Maternal allergy is associated with surface-bound IgE on cord blood basophils.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Article
- Neonatal Fc receptor (FcRn) and maternal-to-newborn IgE absorption.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe mechanism(s) responsible for the acquisition of maternal antibody isotypes other than IgG are not fully understood.
objectiveTo define the ability of the neonatal Fc receptor for IgG uptake (FcRn) to mediate intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.
methodsC57BL/6 allergic ovalbumin (OVA)-immune foster mothers were generated to nurse naïve FcRn(+/-) or FcRn(-/-) progeny. At the time of weaning, serum levels of OVA-specific antibodies and IgG(1) anti-IgE/IgE immune complexes were determined in allergic foster mothers and FcRn(+/+), FcRn(+/-), or FcRn(-/-) breastfed offspring. In separate experiments, FcRn(+/-) or FcRn(-/-) neonatal mice were gavage fed TNP-specific IgE as IgG(1) anti-IgE/IgE immune complexes, IgG(1) isotype control and IgE, or IgE alone. Mice were killed 2 h after feeding to determine serum levels and biological activity of absorbed TNP-specific IgE.
resultsAs expected, the absorption of maternal OVA-specific IgG(1) in FcRn(-/-) offspring was at levels 10(3) -10(4) less than observed in FcRn(+/+) or FcRn(+/-) offspring. Surprisingly, FcRn expression also influenced the absorption of maternal IgE. OVA-specific IgE was detected in FcRn(+/+) and FcRn(+/-) offspring, but not in FcRn(-/-) offspring. IgG(1) anti-IgE/IgE immune complexes were detected in allergic foster mothers and correlated strongly with levels in FcRn(+/+) and FcRn(+/-) offspring (ρ = 0.88, P < 0.0001). Furthermore, FcRn expression was required for neonatal mice to absorb TNP-specific IgE when fed as IgG(1) anti-IgE/IgE immune complexes. When immune complexes were generated with IgG(1) anti-IgE directed against the Cε4 domain, the absorbed IgE was able to function in antigen-dependent basophil degranulation. CONCLUSIONS AND CLINICAL RELEVANCE: These data demonstrate a novel mechanism by which FcRn may facilitate absorption of maternal antibodies other than IgG. These findings are clinically relevant because FcRn mediates the transplacental passage of maternal IgG to the fetus. This raises the possibility that FcRn could mediate the transplacental passage of maternal IgE as IgG anti-IgE/IgE immune complexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.