ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2012
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Association of polymorphisms in TLR2 and TLR4 with asthma risk: An update meta-analysis.Medicine · 2017Pooled it
- Association of HLA-DRA, HLA-DQA1, and IL-6 gene variations with susceptibility to multiple sclerosis.Molecular biology reports · 2025Article
- Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease.Lupus science & medicine · 2025Article
- Lung CD4Cell reports · 2025Article
- Association between bronchial asthma and TSLP gene polymorphism: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
- Review
- Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.Genome medicine · 2022Article
- Identification of potential key genes for immune infiltration in childhood asthma by data mining and biological validation.Frontiers in genetics · 2022Article
- Genome-Wide Association Study of Korean Asthmatics: A Comparison With UK Asthmatics.Allergy, asthma & immunology research · 2021Article
- Potential Metabolic Biomarkers in Adult Asthmatics.Metabolites · 2021Review
- Targeted resequencing showing novel common and rare genetic variants increases the risk of asthma in the Chinese Han population.Journal of clinical laboratory analysis · 2021Article
- The Transcriptome Characteristics of Severe Asthma From the Prospect of Co-Expressed Gene Modules.Frontiers in genetics · 2021Article
- Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets.BMC pulmonary medicine · 2020Article
- Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma.BMC medical genomics · 2020Article
- Comprehensive functional annotation of susceptibility variants associated with asthma.Human genetics · 2020Article
- A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity.PLoS genetics · 2019Article
- Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.The Lancet. Respiratory medicine · 2019Article
- Reconstructing recent population history while mapping rare variants using haplotypes.Scientific reports · 2019Article
- Lessons Learned From GWAS of Asthma.Allergy, asthma & immunology research · 2019Review
- Host Components Contributing to Respiratory Syncytial Virus Pathogenesis.Frontiers in immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 14 institutions in 3 countries.
Funding
Abstract
backgroundAsthma is a common chronic respiratory disease in children and adults. An important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes (e.g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies.
objectiveTo identify genetic variants associated with asthma affection status using genome-wide association data.
methodsWe describe results from a genome-wide association study on asthma performed in 3855 subjects using a panel of 455 089 single nucleotide polymorphisms (SNPs).
resultThe genome-wide association study resulted in the prioritization of 33 variants for immediate follow-up in a multi-staged replication effort. Of these, a common polymorphism (rs9272346) localizing to within 1 Kb of HLA-DQA1 (chromosome 6p21.3) was associated with asthma in adults (P-value = 2.2E-08) with consistent evidence in the more heterogeneous group of adults and children (P-value = 1.0E-04). Moreover, some genes identified in prior asthma GWAS were nominally associated with asthma in our populations.
conclusionOverall, our findings further replicate the HLA-DQ region in the pathogenesis of asthma. HLA-DQA1 is the fourth member of the HLA family found to be associated with asthma, in addition to the previously identified HLA-DRA, HLA-DQB1 and HLA-DQA2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.