ArticleBMC evolutionary biology2012
The evolution of the class A scavenger receptors.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes.International journal of molecular sciences · 2023Review
- Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.Genes & genomics · 2021Article
- Pattern discovery and disentanglement on relational datasets.Scientific reports · 2021Article
- Scavenger Receptor A1 Mediates the Uptake of Carboxylated and Pristine Multi-Walled Carbon Nanotubes Coated with Bovine Serum Albumin.Nanomaterials (Basel, Switzerland) · 2021Article
- Interactions of ferritin with scavenger receptor class A members.The Journal of biological chemistry · 2020Article
- RNA-protein correlation of liver toxicity markers in HepaRG cells.EXCLI journal · 2020Article
- Class A scavenger receptor expression and function in eight novel tadpole cell lines from the green frog (Lithobates clamitans) and the wood frog (Lithobates sylvatica).Cytotechnology · 2019Article
- Article
- Discovery and disentanglement of aligned residue associations from aligned pattern clusters to reveal subgroup characteristics.BMC medical genomics · 2018Article
- PEG-Peptide Inhibition of Scavenger Receptor Uptake of Nanoparticles by the Liver.Molecular pharmaceutics · 2018Article
- Revealing Subtle Functional Subgroups in Class A Scavenger Receptors by Pattern Discovery and Disentanglement of Aligned Pattern Clusters.Proteomes · 2018Article
- Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes.Molecular biology and evolution · 2018Article
- SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1/2, STAT3, and AKT signaling pathways.Molecular and cellular biochemistry · 2017Article
- A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function.Immunology and cell biology · 2016Article
- Structure-Activity Relationship of PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors for Non-Viral Gene Delivery.Molecular pharmaceutics · 2015Article
- Sensors of Infection: Viral Nucleic Acid PRRs in Fish.Biology · 2015Review
- The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors.Frontiers in immunology · 2015Article
- Scavenger Receptors: Emerging Roles in Cancer Biology and Immunology.Advances in cancer research · 2015Review
- Standardizing scavenger receptor nomenclature.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising the question as to whether it is appropriate to group them as a family based on their ligand binding abilities.
resultsTo investigate these relationships, we defined the domain architecture of each of the 5 members followed by collecting and annotating class A scavenger receptor mRNA and amino acid sequences from publicly available databases. Phylogenetic analyses, sequence alignments, and permutation tests revealed a common evolutionary ancestry of these proteins, indicating that they form a protein family. We postulate that 4 distinct gene duplication events and subsequent domain fusions, internal repeats, and deletions are responsible for the diverse protein structures and functions of this family. Despite variation in domain structure, there are highly conserved regions across all 5 members, indicating the possibility that these regions may represent key conserved functional motifs.
conclusionsWe have shown with significant evidence that the 5 members of the class A scavenger receptors form a protein family. We have indicated that these receptors have a common origin which may provide insight into future functional work with these proteins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.