ArticleParticle and fibre toxicology2012
Critical role of surface chemical modifications induced by length shortening on multi-walled carbon nanotubes-induced toxicity.
Article in Particle and fibre toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 86 citations in OpenAlex.
- A Comprehensive Review on Filled Carbon Nanotubes: Synthesis, Properties and Applications.Chemical reviews · 2026Review
- Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery.Frontiers in pharmacology · 2024Review
- Unveiling the Bio-corona Fingerprinting of Potential Anticancer Carbon Nanotubes Coupled with D-Amino Acid Oxidase.Molecular biotechnology · 2022Article
- Long-Chain Modification of the Tips and Inner Walls of MWCNTs and Their Nanocomposite Reverse Osmosis Membranes.Membranes · 2022Article
- Cationic Carbon Nanoparticles Induce Inflammasome-Dependent Pyroptosis in MacrophagesFrontiers in toxicology · 2022Article
- Anti-inflammatory effect of gold nanoparticles supported on metal oxides.Scientific reports · 2021Article
- Review
- The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method.Particle and fibre toxicology · 2020Article
- Quantitative Flow Cytometric Evaluation of Oxidative Stress and Mitochondrial Impairment in RAW 264.7 Macrophages after Exposure to Pristine, Acid Functionalized, or Annealed Carbon Nanotubes.Nanomaterials (Basel, Switzerland) · 2020Article
- DNA nanovaccines prepared using LemA antigen protect Golden Syrian hamsters against Leptospira lethal infection.Memorias do Instituto Oswaldo Cruz · 2020Article
- Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells.International journal of molecular sciences · 2019Article
- Targeting myeloid regulators by paclitaxel-loaded enzymatically degradable nanocups.Nanoscale · 2018Article
- Exposures to nanoparticles and fibers during injection molding and recycling of carbon nanotube reinforced polycarbonate composites.Journal of exposure science & environmental epidemiology · 2017Article
- Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study.International journal of nanomedicine · 2017Article
- Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis.Redox biology · 2016Article
- Copper oxide nanoparticle toxicity profiling using untargeted metabolomics.Particle and fibre toxicology · 2016Article
- Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications.Toxicology and applied pharmacology · 2016Review
- Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength(©) C100 after a 90-day nose-only inhalation exposure of rats.Particle and fibre toxicology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the increasing use of carbon nanotubes (CNT) in composite materials and their possible expansion to new areas such as nanomedicine which will both lead to higher human exposure, a better understanding of their potential to cause adverse effects on human health is needed. Like other nanomaterials, the biological reactivity and toxicity of CNT were shown to depend on various physicochemical characteristics, and length has been suggested to play a critical role. We therefore designed a comprehensive study that aimed at comparing the effects on murine macrophages of two samples of multi-walled CNT (MWCNT) specifically synthesized following a similar production process (aerosol-assisted CVD), and used a soft ultrasonic treatment in water to modify the length of one of them. We showed that modification of the length of MWCNT leads, unavoidably, to accompanying structural (i.e. defects) and chemical (i.e. oxidation) modifications that affect both surface and residual catalyst iron nanoparticle content of CNT. The biological response of murine macrophages to the two different MWCNT samples was evaluated in terms of cell viability, pro-inflammatory cytokines secretion and oxidative stress. We showed that structural defects and oxidation both induced by the length reduction process are at least as responsible as the length reduction itself for the enhanced pro-inflammatory and pro-oxidative response observed with short (oxidized) compared to long (pristine) MWCNT. In conclusion, our results stress that surface properties should be considered, alongside the length, as essential parameters in CNT-induced inflammation, especially when dealing with a safe design of CNT, for application in nanomedicine for example.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.