PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK.

Alfred Ayala, Yanli Ding, Rebecca J Rhee, Lesley A Doughty, Patrician S Grutkoski, Chun-Shiang Chung

Abstract read

In one paragraph

Article in Recent research developments in immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 77% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alfred AyalaDivision of Surgical Research, Department of Surgery, Brown University School of Medicine and Hasbro/Rhode Island Hospital, Providence, RI 02903.

Yanli Ding

Rebecca J Rhee

Lesley A Doughty

Patrician S Grutkoski

Chun-Shiang Chung

Rhode Island Hospital · US

Funding

DIFFERENTIAL EFFECTS OF SEPSIS ON MACROPHAGE FUNCTIONR01GM046354 · NIGMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI AYALA, ALFRED · 1999 to 2016

$4.5M

PROGRAMMED CELL DEATH: ROLE IN SEPTIC IMMUNE SUPPRESSIONR01GM053209 · NIGMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI AYALA, ALFRED · 1995 to 2013

$3.0M

NIGMS NIH HHS R01 GM046354NIGMS NIH HHS R01 GM053209

6 · The paper itself

Abstract

Despite the recent advances in contemporary therapeutic, operative as well as supportive care sepsis and its associated co-morbidity/mortality are still a common occurrence in the critically ill trauma/surgical patient. Thus, it remains important to continue to expand our understanding of pathological components which drive the development of immune dysfunction contributing to subsequent multiple organ failure. Here we overview some of the immuno-pathological processes, cells and mediators which may play a role in the development of this immune dysfunctional condition.

Identifiers

PMID23181245

PMCPMC3505192

OpenAlexW2394758595

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.