ArticleBiological and biomedical reports2012
Neural stem cells in the adult human brain.
Article in Biological and biomedical reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Integration of Metabolic Pathways and Micronutrient Signals Influences Neurodevelopment by Modulating Neural Stem Cell Dynamics.Molecular neurobiology · 2026Review
- Article
- Impact of Apolipoprotein E Genotype on Neurocognitive Function in Patients With Brain Metastases: An Analysis of NRG Oncology's RTOG 0614.International journal of radiation oncology, biology, physics · 2024Article
- Neural Stem Cell-based Regenerative Therapy: A New Approach to Diabetes Treatment.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Radiation-Induced Cognitive Decline: Challenges and Solutions.Cancer management and research · 2024Review
- Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.Biomaterials science · 2023Article
- Review
- Learning cell identity in immunology, neuroscience, and cancer.Seminars in immunopathology · 2023Review
- Stem Cell Homing in Intrathecal Applications and Inspirations for Improvement Paths.International journal of molecular sciences · 2022Review
- Targeting PI3K by Natural Products: A Potential Therapeutic Strategy for Attention-deficit Hyperactivity Disorder.Current neuropharmacology · 2022Review
- Review
- Neural Stem Cells: What Happens When They Go Viral?Viruses · 2021Review
- Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation.Histology and histopathology · 2021Review
- Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease.Alzheimer's research & therapy · 2020Article
- Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro.Scientific reports · 2020Article
- Therapeutic Plasticity of Neural Stem Cells.Frontiers in neurology · 2020Review
- Calcium Channels in Adult Brain Neural Stem Cells and in Glioblastoma Stem Cells.Frontiers in cellular neuroscience · 2020Review
- POLR3-Related Leukodystrophy: Exploring Potential Therapeutic Approaches.Frontiers in cellular neuroscience · 2020Article
- Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology.Molecules (Basel, Switzerland) · 2019Review
- Preliminary Studies on Immune Response and Viral Pathogenesis of Zika Virus in Rhesus Macaques.Pathogens (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
For decades, it was believed that the adult brain was a quiescent organ unable to produce new neurons. At the beginning of the1960's, this dogma was challenged by a small group of neuroscientists. To date, it is well-known that new neurons are generated in the adult brain throughout life. Adult neurogenesis is primary confined to the subventricular zone (SVZ) of the forebrain and the subgranular zone of the dentate gyrus within the hippocampus. In both the human and the rodent brain, the primary progenitor of adult SVZ is a subpopulation of astrocytes that have stem-cell-like features. The human SVZ possesses a peculiar cell composition and displays important organizational differences when compared to the SVZ of other mammals. Some evidence suggests that the human SVZ may be not only an endogenous source of neural precursor cells for brain repair, but also a source of brain tumors. In this review, we described the cytoarchitecture and cellular composition of the SVZ in the adult human brain. We also discussed some clinical implications of SVZ, such as: stem-cell-based therapies against neurodegenerative diseases and its potential as a source of malignant cells. Understanding the biology of human SVZ and its neural progenitors is one of the crucial steps to develop novel therapies against neurological diseases in humans.
Identifiers
23181200PMC3505091What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.