Evidence map›Paper›PMID 23181199›Full record

ArticleCellular logistics2012

EHDs meet the retromer: Complex regulation of retrograde transport.

Jing Zhang, Naava Naslavsky, Steve Caplan

Open access · hybridAbstract read
In one paragraph

Article in Cellular logistics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. A missense mutation inFrontiers in cell and developmental biology · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Retromer in Synaptic Function and Pathology.Frontiers in synaptic neuroscience · 2018
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. BMP signaling requires retromer-dependent recycling of the type I receptor.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jing ZhangDepartment of Biochemistry and Molecular Biology and Eppley Cancer Center; University of Nebraska Medical Center; Omaha, NE USA.
Naava Naslavsky
Steve Caplan
University of Nebraska Medical Center · USUniversity of Nebraska at Omaha · US

Funding

Regulation of EHD protein function by molecular partner interactionsR01GM087455 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CAPLAN, STEVEN H, SORGEN, PAUL L · 2010 to 2013
$1.1M
NIGMS NIH HHS R01 GM087455
6 · The paper itself

Abstract

Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. This mini-review focuses on recent findings and discusses the regulation of the retromer complex by EHD proteins and the novel EHD1 interaction partner, Rabankyrin-5 (Rank-5).

Identifiers

PMID23181199
PMCPMC3498075
OpenAlexW2043422619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.