Evidence map›Paper›PMID 23181145›Full record

ArticleCardiovascular engineering and technology2011

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges.

Vivek A Kumar, Luke P Brewster, Jeffrey M Caves, Elliot L Chaikof

Abstract read
In one paragraph

Article in Cardiovascular engineering and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 119 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Vivek A KumarDepartment of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA 30332.
Luke P Brewster
Jeffrey M Caves
Elliot L Chaikof
Emory University · USGeorgia Institute of Technology · USHarvard University · US

Funding

MEMBRANE-MIMETIC ASSEMBLIES FOR ENDOTHELIAL MIGRATIONR01HL056819 · NHLBI · EMORY UNIVERSITY · PI CHAIKOF, ELLIOT · 1998 to 2016
$5.2M
A Bioinspired Small Diameter Vascular ConduitR01HL083867 · NHLBI · EMORY UNIVERSITY · PI CHAIKOF, ELLIOT · 2006 to 2010
$3.8M
NHLBI NIH HHS R01 HL056819NHLBI NIH HHS R01 HL083867
6 · The paper itself

Abstract

Vascular disease results in the decreased utility and decreased availability of autologus vascular tissue for small diameter (< 6 mm) vessel replacements. While synthetic polymer alternatives to date have failed to meet the performance of autogenous conduits, tissue-engineered replacement vessels represent an ideal solution to this clinical problem. Ongoing progress requires combined approaches from biomaterials science, cell biology, and translational medicine to develop feasible solutions with the requisite mechanical support, a non-fouling surface for blood flow, and tissue regeneration. Over the past two decades interest in blood vessel tissue engineering has soared on a global scale, resulting in the first clinical implants of multiple technologies, steady progress with several other systems, and critical lessons-learned. This review will highlight the current inadequacies of autologus and synthetic grafts, the engineering requirements for implantation of tissue-engineered grafts, and the current status of tissue-engineered blood vessel research.

Identifiers

PMID23181145
PMCPMC3505086
OpenAlexW1969256502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.