ArticleExperimental and therapeutic medicine2012
Sodium hyaluronate as a drug-release system for VEGF 165 improves graft revascularization in anterior cruciate ligament reconstruction in a rabbit model.
Article in Experimental and therapeutic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- What Factors Influence the Biomechanical Properties of Allograft Tissue for ACL Reconstruction? A Systematic Review.Clinical orthopaedics and related research · 2017Pooled it
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Technology Update in Management of Multi-Ligament Knee Injuries.Indian journal of orthopaedics · 2024Review
- Potential application of let-7a antagomir in injured peripheral nerve regeneration.Neural regeneration research · 2023Article
- The Role of Vascular Endothelial Growth Factor in Tendon Healing.Frontiers in physiology · 2021Review
- Revascularization to the bone tunnel wall after anterior cruciate ligament reconstruction may relate to the distance from the vessels.Knee surgery & related research · 2020Article
- Osteoprotegerin/bone morphogenetic protein 2 combining with collagen sponges on tendon-bone healing in rabbits.Journal of bone and mineral metabolism · 2020Article
- Recombinant platelet-derived growth factor-BB and hyaluronic acid stimulates knee cartilage regeneration by forming higher chondrocytes count and lower YKL-40 level in rats model.Journal of clinical orthopaedics and trauma · 2020Article
- Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices.Journal of controlled release : official journal of the Controlled Release Society · 2019Review
- [Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Article
- Systematic Review of Biological Modulation of Healing in Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2014Review
- Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injury.Muscles, ligaments and tendons journal · 2014Article
- Recombinant platelet derived growth factor-BB and hyaluronic acid effect in rat osteoarthritis models.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graft remodeling following anterior cruciate ligament (ACL) reconstruction requires a long period of recovery in which vascular endothelial growth factor (VEGF) plays an important role. The short half-life of exogenous VEGF, however, restricts its use. The aim of this study was to investigate sodium hyaluronate (SH) as a delivery system for VEGF in graft revascularization. Non-cumulative release into phosphate-buffered saline (PBS) was firstly measured spectrophotometrically for 1-4 days. Allogeneic bone-patellar tendon-bone (B-PT-B) was soaked in the VEGF/SH formulation and implanted in a rabbit model to regenerate the ACL and observe the vascularization and biomechanical properties. The results revealed that a steady state was achieved after ∼40 h in non-cumulative measurements. The release plotted as a function of the square root of time was consistent with a largely diffusion-controlled release system. At 2, 4 and 8 weeks, the microvessel density of grafts was higher in the VEGF/SH-treated group compared to the control groups. Although there was a temporary decline at 2 weeks, the stiffness and maximum tensile load of the experimental group was significantly greater than that of the control group at 4 and 8 weeks (P<0.01). Our findings suggest that SH can be used as a good carrier of VEGF, which can improve the early revascularization and biomechanical properties of B-PT-B allografts after ACL reconstruction.
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Registered trials
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