ArticleResearch in pharmaceutical sciences2012
A study of the effects of Cydonia oblonga Miller (Quince) on TNBS-induced ulcerative colitis in rats.
Article in Research in pharmaceutical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Quince Gel Attenuates Experimental Ulcerative Colitis Through Antioxidant, Anti-Inflammatory and Mucosal Repair Mechanisms: Integrated Histopathological, Bioinformatic and Molecular Docking Analyses.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Quince phenolics and dietary fibers: changes during in vitro digestion.European journal of nutrition · 2025Article
- Niosome-Based Hydrogel of Quince Extract: A Promising Strategy for Expedited Full-thickness Wound Healing in Rat.Current drug delivery · 2025Article
- Antioxidant activity and Inhibitory effects of Cydonia oblonga Miller. leaves extracts against calcium oxalate stones.Urolithiasis · 2024Article
- The Synergistic Effect of Quince Fruit and Probiotics (Nutrients · 2023Article
- Cardiovascular Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Investigating the effects of bark extract and volatile oil ofToxicology research · 2021Article
- Effect of Herbal Medicine on Fertility Potential in Experimental Animals - an Update Review.Materia socio-medica · 2020Review
- Protective Effects ofIranian journal of pharmaceutical research : IJPR · 2020Article
- Ameliorative effect of galantamine on acetic acid-induced colitis in rats.Research in pharmaceutical sciences · 2019Article
- Anti-inflammatory effects of alosetron mediated through 5-HTResearch in pharmaceutical sciences · 2019Article
- Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats.Inflammopharmacology · 2018Article
- Traditional Persian topical medications for gastrointestinal diseases.Iranian journal of basic medical sciences · 2017Review
- Cytotoxic effects ofResearch in pharmaceutical sciences · 2016Article
- Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals.Frontiers in pharmacology · 2016Review
- Design, formulation, and evaluation of ginger medicated chewing gum.Advanced biomedical research · 2016Article
- The effect of hydroalcoholic extract from the leaves of Moringa peregrina (Forssk.) Fiori. on blood pressure and oxidative status in dexamethasone-induced hypertensive rats.Advanced biomedical research · 2015Article
- Effect of Hydroalcoholic Extract of Cydonia oblonga Miller (Quince) on Sexual Behaviour of Wistar Rats.Advances in pharmacological sciences · 2014Article
- Protective effects of the Morus alba L. leaf extracts on cisplatin-induced nephrotoxicity in rat.Research in pharmaceutical sciences · 2013Article
- Effects of Carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in rats.Research in pharmaceutical sciences · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cydonia oblonga Miller (Quince) from Rosaceae family is a fruit tree cultivated in many countries mainly in Iran. This study was carried out to investigate the effect of quince juice (QJ) and quince hydroalcoholic extract (QHE) on ulcerative colitis (UC) induced by TNBS (trinitrobenzene sulfonic acid) in rats. Rats were grouped (n=6) and fasted for 36 h before colitis induction. TNBS was instilled into the colon with a hydroalcoholic carrier and then treatments were made for 5 days starting 6 h after colitis induction with different doses of QJ (200, 400, 800 mg/kg), QHE (200, 500 & 800 mg/kg) orally, QJ (400 mg/kg) and QHE (200 and 500 mg/kg) intraperitoneally. The colon tissue was removed and tissue damages were scored after macroscopic and histopathologic assessments. Albeit the examined doses of QJ and QHE were apparently effective to reduce the extent of UC lesions, only the greatest doses (500 and 800 mg/kg) resulted in significant alleviation. Weight/Length ratio as an illustrative of tissue inflammation and extravasation was also diminished with quince treatments while the results correlated with macroscopic and histopathologic evaluations. These data suggest that QJ and QHE were effective to diminish inflammation and ulcer indices in this murine model of acute colitis. Although QHE with different doses was effective in induced colitis, the dose and/or route of administration dependency was not confirmed. So quince fractions could be considered as a suitable anticolitic alternative, however further studies are needed to support this hypothesis for clinical setting.
Indexed as
Identifiers
23181087PMC3501898W1887926807What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.