ArticleWorld journal of gastroenterology2012
Octreotide in Hennekam syndrome-associated intestinal lymphangiectasia.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Primary intestinal lymphangiectasia: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins).Orphanet journal of rare diseases · 2025Review
- Newfound features associated with Hennekam Syndrome (Clinical case reports · 2023Article
- Pathophysiology, Diagnosis, and Management of Canine Intestinal Lymphangiectasia: A Comparative Review.Animals : an open access journal from MDPI · 2022Review
- Etiology and Management of Pediatric Intestinal Failure: Focus on the Non-Digestive Causes.Nutrients · 2021Review
- Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations.The Journal of allergy and clinical immunology · 2020Review
- Comparative pathophysiology and management of protein-losing enteropathy.Journal of veterinary internal medicine · 2019Review
- Octreotide Use in Neonates: A Case Series.Drugs in R&D · 2018Article
- Hennekam Syndrome: A Case Report.Annals of rehabilitation medicine · 2018Article
- Intestinal Lymphangiectasia: Insights on Management and Literature Review.The American journal of case reports · 2016Review
- How to treat an extensive form of primary intestinal lymphangiectasia?World journal of gastroenterology · 2015Article
- Primary intestinal lymphangiectasia: Minireview.World journal of clinical cases · 2014Review
- Use of octreotide for the treatment of protein-losing enteropathy in dogs: Retrospective study of 18 cases.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of disorders have been described to cause protein losing enteropathy (PLE) in children. Primary intestinal lymphangiectasia (PIL) is one mechanism leading to PLE. Few syndromes are associated with PIL; Hennekam syndrome (HS) is one of them. The principal treatment for PIL is a high protein, low fat diet with medium chain triglycerides supplementation. Supportive therapy includes albumin infusion. Few publications have supported the use of octreotide to diminish protein loss and minimize hypoalbuminemia seen in PIL. There are no publications on the treatment of PIL with octreotide in patients with HS. We report two children with HS and PLE in which we used octreotide to decrease intestinal protein loss. In one patient, octreotide increased serum albumin to an acceptable level without further need for albumin infusions. The other patient responded more dramatically with near normal serum albumin levels and cessation of albumin infusions. In achieving a good response to octreotide in both patients, we add to the publications supporting the use of octreotide in PIL and suggest that octreotide should be tried in patients with PIL secondary to HS. To the best of our knowledge, this is the first case report on the use of octreotide in HS-associated PIL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.