Trial reportWorld journal of gastroenterology2012
Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.
Trial report in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Efficacy of probiotics pretreatment inAnnals of medicine · 2025Pooled it
- Efficacy and safety of probiotics in eradicating Helicobacter pylori: A network meta-analysis.Medicine · 2019Pooled it
- Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis.BMJ (Clinical research ed.) · 2015Pooled it
- Probiotics in Helicobacter pylori eradication therapy: a systematic review and meta-analysis.World journal of gastroenterology · 2015Pooled it
- Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy.World journal of gastroenterology · 2014Pooled it
- Pooled it
- Intelligent Algorithm-Based Gastrointestinal X-Ray Examination in Evaluating the Therapeutic Effect of Probiotics Combined with Triple Therapy on Children withContrast media & molecular imaging · 2022Trial
- [Clinical effects of different therapeutic regimens for Helicobacter pylori infection in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Trial
- Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study.BMC gastroenterology · 2013Trial
- Effect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children.Indian journal of pharmacologyTrial
- Two-week triple therapy has a higher Helicobacter pylori eradication rate than 1-week therapy: A single-center randomized study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationTrial
- Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review.Frontiers in cell and developmental biology · 2024Review
- Probiotics and autoprobiotics for treatment ofWorld journal of clinical cases · 2023Review
- Efficacy and safety ofFrontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
- Characterization of gut microbiome and metabolome inWorld journal of gastroenterology · 2021Article
- Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment.Frontiers in microbiology · 2021Review
- Utilizing Probiotics for the Prevention and Treatment of Gastrointestinal Diseases.Frontiers in microbiology · 2021Review
- Lactobacillus spp. attenuate antibiotic-induced immune and microbiota dysregulation in honey bees.Communications biology · 2020Article
- Clinical Outcomes of Standard Triple Therapy Plus Probiotics or Concomitant Therapy forGut and liver · 2018Article
- Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview.Gastroenterology and hepatology from bed to bench · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori) infection.
methodsThis open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid, clarithromycin 500 mg bid, and amoxicillin 1000 mg bid; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 10(7)Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods.
resultsPP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction.
conclusionAdministration of probiotics before or after standard triple therapy may improve H. pylori eradication rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.