ArticleJournal of lipid research2013
Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Plant Sterol-Enriched Palm Oil Intervention to Improve Lipid Profile and Inflammation Status in Hyperlipidemic Individuals.Nutrients · 2024Trial
- Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe.The Journal of pediatrics · 2017Trial
- Factors Affecting Circulating Phytosterol Levels: Toward an Integrated Understanding of Atherogenicity and Atheroprotection by Dietary and Circulating Phytosterols.Current atherosclerosis reports · 2025Review
- Male fertility and high cholesterol: to treat or not to treat?Endocrine · 2024Article
- Dietary phytosterols induce infertility in female mice via epigenomic modulations.Communications biology · 2024Article
- Association of ABCG5 and ABCG8 Transporters with Sitosterolemia.Advances in experimental medicine and biology · 2024Review
- Phytosterols and Cardiovascular Risk Evaluated against the Background of Phytosterolemia Cases-A German Expert Panel Statement.Nutrients · 2023Article
- Phytosterols and Cardiovascular Disease.Current atherosclerosis reports · 2021Review
- Sitosterolemia: Twenty Years of Discovery of the Function ofInternational journal of molecular sciences · 2021Review
- Cross-Sectional Study of Plant Sterols Intake as a Basis for Designing Appropriate Plant Sterol-Enriched Food in Indonesia.Nutrients · 2021Article
- Case Report: Next Generation Sequencing in Clinical Practice-A Real Tool for Ending the Protracted Diagnostic Odyssey.Frontiers in cardiovascular medicine · 2021Article
- Mice lacking global Stap1 expression do not manifest hypercholesterolemia.BMC medical genetics · 2020Article
- ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion.Biochemical Society transactions · 2019Review
- ABCG5 and ABCG8: more than a defense against xenosterols.Journal of lipid research · 2018Review
- Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-induced hypercholesterolaemia.Scientific reports · 2018Article
- Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.PLoS genetics · 2017Article
- Plant sterol enriched functional food and atherosclerosis.British journal of pharmacology · 2017Review
- Sitosterolemia: a review and update of pathophysiology, clinical spectrum, diagnosis, and management.Annals of pediatric endocrinology & metabolism · 2016Review
- Kinetics of phytosterol metabolism in neonates receiving parenteral nutrition.Pediatric research · 2015Article
- Relative roles of ABCG5/ABCG8 in liver and intestine.Journal of lipid research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation of the human disease sitosterolemia (MIM 210250) has shed light not only on the pathways by which dietary sterols may traffic but also on how the mammalian body rids itself of cholesterol and defends against xenosterols. Two genes, ABCG5 and ABCG8, located at the sitosterolemia locus, each encodes a membrane-bound ABC half-transporter and constitutes a functional unit whose activity has now been shown to account for biliary and intestinal sterol excretion. Knockout mice deficient in Abcg5 or Abcg8 recapitulate many of the phenotypic features of sitosterolemia. During the course of our studies to characterize these knockout mice, we noted that these mice, raised on normal rodent chow, exhibited infertility as well as loss of abdominal fat. We show that, although sitosterolemia does not lead to any structural defects or to any overt endocrine defects, fertility could be restored if xenosterols are specifically blocked from entry and that the loss of fat is also reversed by a variety of maneuvers that limit xenosterol accumulation. These studies show that xenosterols may have a significant biological impact on normal mammalian physiology and that the Abcg5 or Abcg8 knockout mouse model may prove useful in investigating the role of xenosterols on mammalian physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.