ArticleNucleic acids research2013
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Deficiency of Werner RecQ-type DNA helicase causes premature malnutrition in zebrafish.iScience · 2026Article
- How DNA secondary structures drive replication fork instability.DNA repair · 2025Review
- USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.Nature communications · 2024Article
- Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates.Nucleic acids research · 2021Article
- RECQL5 at theFrontiers in cell and developmental biology · 2020Review
- Werner Syndrome Protein and DNA Replication.International journal of molecular sciences · 2018Review
- Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways.Nucleic acids research · 2018Article
- Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids.The Journal of biological chemistry · 2018Article
- Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.Human mutation · 2017Article
- Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts.Pharmaceuticals (Basel, Switzerland) · 2016Article
- RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.DNA repair · 2016Article
- Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.Molecular and cellular biology · 2015Article
- Article
- Human RECQL1 participates in telomere maintenance.Nucleic acids research · 2014Article
- Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.Journal of human genetics · 2014Review
- Human RecQ helicases in DNA repair, recombination, and replication.Annual review of biochemistry · 2014Review
- Article
- RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.Cell cycle (Georgetown, Tex.) · 2012Article
- Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Humans have five RecQ helicases, whereas simpler organisms have only one. Little is known about whether and how these RecQ helicases co-operate and/or complement each other in response to cellular stress. Here we show that RECQL5 associates longer at laser-induced DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts physically and functionally with WRN both in vivo and in vitro. RECQL5 co-operates with WRN on synthetic stalled replication fork-like structures and stimulates its helicase activity on DNA fork duplexes. Both RECQL5 and WRN re-localize from the nucleolus into the nucleus after replicative stress and significantly associate with each other during S-phase. Further, we show that RECQL5 is essential for cell survival in the absence of WRN. Loss of both RECQL5 and WRN severely compromises DNA replication, accumulates genomic instability and ultimately leads to cell death. Collectively, our results indicate that RECQL5 plays both co-operative and complementary roles with WRN. This is an early demonstration of a significant functional interplay and a novel synthetic lethal interaction among the human RecQ helicases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.