ArticleCardiovascular research2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Article in Cardiovascular research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting immune cell recruitment in atherosclerosis.Nature reviews. Cardiology · 2024Review
- Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis.Nature cardiovascular research · 2024Article
- Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential.Journal of clinical medicine · 2021Review
- Inflammatory Chemokines in Atherosclerosis.Cells · 2021Review
- Inflammatory Cell Recruitment in Cardiovascular Disease.Frontiers in cell and developmental biology · 2021Review
- Myeloid Cell Diversity and Impact of Metabolic Cues during Atherosclerosis.Immunometabolism · 2020Article
- T cell subsets and functions in atherosclerosis.Nature reviews. Cardiology · 2020Review
- Integrated miRNA/mRNA Counter-Expression Analysis Highlights Oxidative Stress-Related GenesInternational journal of molecular sciences · 2020Article
- Lymphatic Migration of Immune Cells.Frontiers in immunology · 2019Review
- CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia.Journal of the American Heart Association · 2017Article
- Dendritic cell migration in health and disease.Nature reviews. Immunology · 2017Review
- Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets.Cytokine & growth factor reviews · 2015Review
- Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.Cardiovascular research · 2015Article
- Lymphocyte migration into atherosclerotic plaque.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
- The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR(-/-) mice.Genes & nutrition · 2014Article
- Mechanisms that regulate macrophage burden in atherosclerosis.Circulation research · 2014Review
- Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease.Journal of immunology research · 2014Review
- Isolation, purification and labeling of mouse bone marrow neutrophils for functional studies and adoptive transfer experiments.Journal of visualized experiments : JoVE · 2013Article
- The role of the vascular dendritic cell network in atherosclerosis.American journal of physiology. Cell physiology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aimsRecent evidence suggests that both Ccr7 and its ligands, Ccl19 and Ccl21, are present in mouse and human atherosclerotic plaques; however, the role of Ccr7 in atherogenesis is still controversial. Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis. METHODS AND
resultsCcr7(-/-)ApoE(-/-) double knockout mice and Ccr7(+/+)ApoE(-/-) littermates were generated and maintained on a high-fat Western diet for 8 weeks to induce atherosclerosis. Ccr7(-/-)ApoE(-/-) mice showed an ~80% increase in atherosclerotic lesion size in the whole aorta and a two-fold increase in the aortic root compared with Ccr7(+/+)ApoE(-/-) mice. Ccr7(-/-)ApoE(-/-) mice had increased T cells in the blood, bone marrow, and spleen, as well as in atherosclerotic lesions. Competitive repopulation experiments revealed that T cells from Ccr7(-/-)ApoE(-/-) mice migrated poorly into lymph nodes but better into mouse aortas compared with T cells from Ccr7(+/+)ApoE(-/-) mice. Transplantation of the bone marrow from Ccr7(-/-)ApoE(-/-) mice into lethally irradiated Ccr7(+/+)ApoE(-/-) mice resulted in ~60% more atherosclerotic lesions compared with Ccr7(+/+)ApoE(-/-) donor bone marrow, suggesting that exacerbation was mediated by a Ccr7(+) bone marrow-derived cell(s). Furthermore, in Ccr7(-/-)ApoE(-/-) mice the serum level of IL-12 was markedly increased, whereas the level of transforming growth factor beta (TGF-β) was significantly decreased, suggesting an imbalance of T cell responses in these mice.
conclusionOur data suggest that genetic deletion of Ccr7 exacerbates atherosclerosis by increasing T cell accumulation in atherosclerotic lesions.
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