ArticleAmerican journal of human biology : the official journal of the Human Biology Council
C-reactive protein by pregnancy and lactational status among Filipino young adult women.
Article in American journal of human biology : the official journal of the Human Biology Council. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- C-reactive protein increases with gestational age during pregnancy among Chinese women.American journal of human biology : the official journal of the Human Biology Council · 2016Trial
- Breastfeeding shapes a unique tumor-immune landscape in pregnancy-associated breast cancer from GEICAM-EMBARCAM study.Breast cancer research : BCR · 2026Article
- Variation in maternal lactation practices associated with changes in diurnal maternal inflammation.Scientific reports · 2024Article
- Non-linear and non-additive associations between the pregnancy metabolome and birthweight.Environment international · 2021Article
- The biological age of the heart is consistently younger than chronological age.Scientific reports · 2020Article
- Regulation of inflammation during gestation and birth outcomes: Inflammatory cytokine balance predicts birth weight and length.American journal of human biology : the official journal of the Human Biology Council · 2019Article
- Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women.Scientific reports · 2018Article
- Biomarkers of Nutrition for Development (BOND)-Iron Review.The Journal of nutrition · 2018Review
- C-reactive protein is differentially modulated by co-existing infections, vitamin deficiencies and maternal factors in pregnant and lactating indigenous Panamanian women.Infectious diseases of poverty · 2017Article
- Chronic Stress and C-Reactive Protein in Mothers During the First Postpartum Year.Psychosomatic medicine · 2017Article
- Lower levels of human milk adiponectin predict offspring weight for age: a study in a lean population of Filipinos.Maternal & child nutrition · 2016Article
- Adiposity and Chronic Inflammation in Young Women Predict Inflammation during Normal Pregnancy in the Philippines.The Journal of nutrition · 2016Article
- Links among inflammation, sexual activity and ovulation: Evolutionary trade-offs and clinical implications.Evolution, medicine, and public health · 2015Article
- Relationship of Postpartum Levels of Cystatin and High-Sensitivity C-Reactive Protein and Duration of Lactation in Mothers with Previous Gestational Hypertension or Preeclampsia.Breastfeeding medicine : the official journal of the Academy of Breastfeeding MedicineArticle
- Nutrient intakes associated with elevated serum C-reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya.American journal of human biology : the official journal of the Human Biology CouncilArticle
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesPregnancy and lactation involve adaptations in immune regulation, but little is known about cross-cultural variation in inflammatory changes during pregnancy or lactation. Here we report concentrations of C-reactive protein (CRP) in a large cross-sectional sample of healthy Filipino women who vary in parity, gestational, and lactational status, and who come from a population previously described as having low CRP.
methodsFasting plasma CRP was measured among female participants (ages 20.8-22.4 years) in the Cebu Longitudinal Health and Nutrition Survey (n = 822).
resultsMedian CRP was 0.2 mg/l in nulliparous women and peaked at 2.0 mg/l in women in their 3rd trimester of pregnancy. Parous but post-partum women had higher CRP compared to nulliparous women, which was largely explained by body composition differences as reflected in waist circumference and skinfold measures. Among post-partum women with infants, CRP was similar in women who were currently breastfeeding compared to those who were not.
conclusionsAt Cebu, women late in gestation have 10-fold higher C-reactive protein compared to nulliparous women, with no evidence that lactation is inflammatory. These population-based findings are similar with findings from prior clinic-based studies and are consistent with the maternal immunological adaptations initiated during pregnancy. The tendency of human females to spend more time than females of other great apes in gestation rather than lactation suggests that the human life history strategy involved increased time spent by reproductively aged females in a pro-inflammatory state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.