ArticleGenesis (New York, N.Y. : 2000)2013
Generation and characterization of Osterix-Cherry reporter mice.
Article in Genesis (New York, N.Y. : 2000), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- An immunocompetent, multifluorescent resource for real-time analysis of osteosarcoma progression, metastasis, and response to therapy.Science advances · 2026Article
- Bo-Net: Deep learning-based model for automatic bone stromal cell segmentation of fluorescence microscopy images.PloS one · 2026Article
- Self-propagating wave drives morphogenesis of skull bones in vivo.Nature communications · 2025Article
- Article
- Specialized post-arterial capillaries facilitate adult bone remodelling.Nature cell biology · 2024Article
- Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration.Nature communications · 2024Article
- Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat.Scientific reports · 2022Article
- Article
- A transgenic bacterial artificial chromosome approach to identify regulatory regions that directFrontiers in cell and developmental biology · 2022Article
- Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.Nature communications · 2021Article
- Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering.Biomaterials · 2021Article
- N-cadherin in osteolineage cells modulates stromal support of tumor growth.Journal of bone oncology · 2021Article
- Article
- Dynamic responses of the haematopoietic stem cell niche to diverse stresses.Nature cell biology · 2020Review
- Expression of BSP-GFPtpz Transgene during Osteogenesis and Reparative Dentinogenesis.Journal of dental research · 2020Article
- Osterix-mCherry Expression Allows for Early Bone Detection in a Calvarial Defect Model.Advanced biosystems · 2019Article
- SHP2 regulates intramembranous ossification by modifying the TGFβ and BMP2 signaling pathway.Bone · 2019Article
- Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse.Scientific reports · 2019Article
- Layer-by-layer nanofiber-enabled engineering of biomimetic periosteum for bone repair and reconstruction.Biomaterials · 2018Article
- SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Osterix is a zinc finger containing transcription factor, which functions as a key regulator of osteoblast differentiation. To better understand the temporal and spatial expression of Osterix during embryonic development and in the adult skeleton, we generated Osterix-Cherry reporter mice. Bacterial recombination techniques were employed to engineer a transgenic construct, which consisted of a ∼39 kb DNA fragment encompassing the Osterix/Sp7 gene, but excluding adjacent gene sequences. Osterix reporter expression was characterized at embryonic, neonatal, and adult ages both by itself and in the context of a cross with Bone Sialoprotein (BSP)-Topaz reporter mice. Relative to Osterix, BSP is a more mature marker of osteoblast differentiation. In agreement with osteoblast lineage maturation, Osterix reporter expression preceded BSP reporter expression during embryonic development and spatially appeared in a much broader cell population. Strong Osterix reporter expression was observed in mature osteoblasts and osteocytes. However, weaker Osterix-Cherry positive cells were also observed in the bone marrow, possibly identifying an early osteoprogenitor cell population. Evaluation of Osterix reporter expression in male femur tissue sections from 10 days to 12 weeks of age revealed persistent expression in cells of the osteoblast lineage and a surprising increase in maturing chondrocytes of the growth plate. Also, Osterix reporter expression was transiently detected in the kidney after birth.
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