Evidence map›Paper›PMID 23180362›Full record

ArticleJournal of clinical immunology2013

Increased plasma interleukin-32 expression in patients with neuromyelitis optica.

Honghao Wang, Kai Wang, Conghui Wang, Fangcheng Xu, Wei Qiu, Xueqiang Hu

Abstract read
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In one paragraph

Article in Journal of clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  8. Review
  9. The Biology and Role of Interleukin-32 in Tuberculosis.Journal of immunology research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Honghao WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Kai Wang
Conghui Wang
Fangcheng Xu
Wei Qiu
Xueqiang Hu
First Affiliated Hospital of Anhui Medical University · CNThird Affiliated Hospital of Sun Yat-sen University · CNAnhui Medical University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeuromyelitis optica (NMO) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). The pathogenesis of NMO remains unclear. IL-32 is emerging as a critical molecule in the pathophysiology of immune-mediated chronic inflammatory diseases. Whether IL-32 levels are elevated in NMO patients is unclear. We aimed to determine whether IL-32 levels are elevated in NMO patients and explore its relationship with IL-6, IL-17, and Expanded Disability Status Scale (EDSS) scores.

methodsPlasma IL-32α, IL-6 and IL-17A were measured by enzyme-linked immunosorbent assay in NMO (n = 26), MS (n = 23) and 22 healthy controls.

resultsWe found IL-32α levels were higher in NMO patients compared with MS (p = 0.020) and healthy controls (p = 0.00001). IL-32α levels were increased in MS patients compared with controls (p = 0.009). IL-32α positively correlated with IL-6 and IL-17A levels and EDSS scores in NMO patients.

conclusionsIn summary, plasma IL-32α levels are associated with inflammatory responses in NMO patients.

Indexed as

AdultCase-Control StudiesFemaleHumansInterleukin-17Interleukin-6InterleukinsMaleMiddle AgedNeuromyelitis OpticaIL32 protein, humanInterleukin-17Interleukin-6Interleukins

Identifiers

PMID23180362
OpenAlexW2030335804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.