ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2013
Comparative study of laser-induced choroidal neovascularization in rats by paraffin sections, frozen sections and high-resolution optical coherence tomography.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Durable 3D murine ex vivo retina glaucoma models for optical coherence tomography.Biomedical optics express · 2023Article
- Article
- Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology.Translational vision science & technology · 2020Article
- [Importance of investigation of fetal eyes : Supplement to fetal autopsy].Der Pathologe · 2017Review
- Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma.Frontiers in neuroscience · 2017Article
- Inhibition of choroidal neovascularization by lentivirus-mediated PEDF gene transfer in rats.International journal of ophthalmology · 2016Article
- A Simple Optical Coherence Tomography Quantification Method for Choroidal Neovascularization.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2015Article
- Article
- Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration.Frontiers in neuroanatomy · 2014Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to demonstrate the value of a quantitative study concerning experimental choroidal neovascularization (CNV) tissue by correlating the paraffin sections and frozen sections with optical coherence tomography (OCT) images.
methodsAfter OCT imaging was performed, four right eyes from the normal Brown Norway (BN) rats were made into paraffin sections and four left eyes were made into frozen sections. Laser photocoagulation was performed on the right eyes of the other 32 BN rats to induce CNV; these rats then were divided into two groups. After the OCT imaging was performed, four eyes were made into serial paraffin sections in Group A or frozen sections in Group B at 1 week after laser photocoagulation, and weekly for 4 weeks. A quantitative comparison of histopathological images and OCT images was performed.
resultsThe thickness of the sensory retina and choroid of normal BN rats in paraffin sections was perceptibly less than that in the frozen sections, and the thickness of the sensory retina in the frozen sections was similar to that measured in the OCT images. The maximum thickness of the CNV tissue in the frozen sections was greater than that in the paraffin sections, but similar to that measured in the OCT images from week 1 to week 4.
conclusionsOnly the frozen sections accurately matched the high-resolution OCT images because of the processing artifacts in the paraffin sections. In further quantitative studies on experimental CNV, the frozen sections may be more preferable if the thickness of the CNV tissue is to be measured and compared.
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