ArticleJournal of neurology2013
Prognostic value of early epileptic seizures on mortality and functional disability in acute stroke: the Dijon Stroke Registry (1985-2010).
Article in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Exploring the Smoking-Epilepsy Nexus: a systematic review and meta-analysis of observational studies : Smoking and epilepsy.BMC medicine · 2024Pooled it
- Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Association between seizures after ischemic stroke and stroke outcome: A systematic review and meta-analysis.Medicine · 2016Pooled it
- Assessment of the incidence and risk factors of early poststroke seizures in Lebanese patients.Brain and behavior · 2021Observational
- Clinical Profile and Outcomes of Early Seizures in Asian Patients With Acute Intracerebral Hemorrhage.Journal of acute medicine · 2019Article
- Seizures Do Not Affect Disability and Mortality Outcomes of Stroke: A Population-Based Study.Journal of clinical medicine · 2019Article
- The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study.Journal of neurology · 2018Article
- Antiepileptic drugs in critically ill patients.Critical care (London, England) · 2018Review
- The Progress of Epilepsy after Stroke.Current neuropharmacology · 2018Review
- Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients.Epilepsia open · 2017Article
- Mortality after primary intracerebral hemorrhage in relation to post-stroke seizures.Journal of neurology · 2017Article
- Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016Article
- Does treatment with t-PA increase the risk of developing epilepsy after stroke?Journal of neurology · 2015Observational
- In vitro cerebrovascular modeling in the 21st century: current and prospective technologies.Pharmaceutical research · 2014Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to evaluate the prognostic value of early epileptic seizures after stroke. All consecutive patients with a first-ever stroke were prospectively identified within the population of Dijon, France, thanks to a population-based registry, from 1985 to 2010. Early epileptic seizures were defined as seizures occurring within 14 days after stroke onset. Outcomes were 1-month and 1-year mortality, and severe functional handicap at discharge. Of the 4,411 stroke patients included, data about seizures were available in 4,358 (98.8, 53.5 % women, mean age, 74.1 ± 14.8 years). Among these patients, 134 (3.1 %) had early seizures. Stroke patients with early seizures differed from those without seizures, as there was a higher proportion of hemorrhagic stroke, higher blood glucose level at admission, smoking status, and more frequent impaired. Higher risks of 1-month and 1-year mortality in patients with early seizures (unadjusted HR 1.45, 95 % CI 1.00-2.10; HR = 1.59, 95 % CI 1.21-2.09, respectively) disappeared (HR 0.71, 95 % CI 0.49-1.08 and HR 0.85, 95 % CI 0.64-1.17) after adjustment for stroke severity and other confounding factors. Early seizures were associated with severe handicap in unadjusted analyses (OR 2.07, 95 % CI 1.46-2.95) but the association was no longer significant after multivariable adjustment (OR 1.12, 95 % CI 0.69-1.83). Early epileptic seizures were not associated with higher risks of mortality at 1 month and 1 year or with unfavorable functional outcome after acute stroke. The adverse effects of epileptic seizures may not be distinguishable from stroke severity, which is strongly related to epileptic seizures.
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