ArticleJournal of molecular neuroscience : MN2013
Expression of RBMX after spinal cord injury in rats.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptomic and pathological analysis of the hnRNP network reveals glial involvement in frontotemporal lobar degeneration pathological subtypes.Brain communications · 2026Article
- Genome-Wide Identification of Microglia-Related RNA-Binding Proteins and Regulated Alternative Splicing in Spinal Cord Injury.ACS omega · 2025Article
- Identification and Characterization of Alternative Splicing Variants and Positive Selection Genes Related to Distinct Growth Rates of Antlers Using Comparative Transcriptome Sequencing.Animals : an open access journal from MDPI · 2022Article
- Cold Shock Induced Protein RBM3 but Not Mild Hypothermia Protects Human SH-SY5Y Neuroblastoma Cells From MPPFrontiers in neuroscience · 2018Article
- RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection.Oncotarget · 2017Review
- PRDM5 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat.Neurochemical research · 2016Article
- Effect of adenovirus-mediated RNA interference of IL-1β expression on spinal cord injury in rats.Spinal cord · 2016Article
- Temporospatial expression of fibulin-1 after acute spinal cord injury in rats.The journal of spinal cord medicine · 2015Article
- Expression of RBMX in the light-induced damage of rat retina in vivo.Cellular and molecular neurobiology · 2015Article
- Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway.Journal of molecular neuroscience : MN · 2015Article
- Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and -catenin pathway after spinal cord injury.Cell cycle (Georgetown, Tex.) · 2015Article
- Matrix metalloproteinase-1 (MMP-1) expression in rat spinal cord injury model.Cellular and molecular neurobiology · 2014Article
- Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.Journal of molecular histology · 2014Article
- Increased Expression of TBP/TFIID after spinal cord injury in adult rats.Cellular and molecular neurobiology · 2014Article
- Spatiotemporal pattern of RNA-binding motif protein 3 expression after spinal cord injury in rats.Cellular and molecular neurobiology · 2014Article
- Up-regulation of FoxN4 expression in adult spinal cord after injury.Journal of molecular neuroscience : MN · 2014Article
- Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats.Journal of molecular neuroscience : MN · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RBMX (RNA-binding motif gene, X chromosome) is a heterogeneous nuclear ribonucleoprotein that associates with the spliceosome, binds RNA, and influences alternative splicing. The gene encoding RBMX is located on chromosome Xq26 and is ubiquitously expressed. However, its expression and function in spinal cord injury are still unclear. In this study, we performed an acute spinal cord contusion injury (SCI) model in adult rats and investigated the dynamic changes of RBMX expression in spinal cord. Western blot and immunohistochemistry analysis revealed that RBMX was present in normal spinal cord. It gradually increased, reached a peak at 1 day, and then declined to basal levels at 14 days after spinal cord injury. Double immunofluorescence staining showed that RBMX immunoreactivity was found in neurons and astrocytes, but not in microglia. Interestingly, RBMX expression was increased predominantly in neurons and astrocytes. Moreover, colocalization of RBMX/proliferating cell nuclear antigen (PCNA) and RBMX/active caspase-3 was detected in GFAP and NeuN, respectively. We also examined the expression profiles of active caspase-3, bcl-2, Bax, and PCNA, whose changes were correlated with the expression profiles of RBMX. In conclusion, this is the first description of RBMX expression in spinal cord injury. Our results suggested that RBMX might play crucial roles in CNS pathophysiology after SCI.
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