Trial reportJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2013
Comparative distribution of complex fractionated atrial electrograms, high dominant frequency (HDF) sites during atrial fibrillation and HDF sites during sinus rhythm.
Trial report in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Atrial fibrillation substrate mapping with emphasis on voltage-based guidance.World journal of cardiology · 2025Review
- Clinical and Structural Factors Affecting Ablation Outcomes in Atrial Fibrillation Patients - A Review.Current cardiology reviews · 2023Review
- Left atrial voltage mapping: defining and targeting the atrial fibrillation substrate.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019Review
- Wavefront direction and cycle length affect left atrial electrogram amplitude.Journal of arrhythmia · 2017Article
- Complex fractionated atrial electrograms, high dominant frequency regions, and left atrial voltages during sinus rhythm and atrial fibrillation.Journal of arrhythmia · 2017Article
- Electrophysiological Perspectives on Hybrid Ablation of Atrial Fibrillation.Journal of atrial fibrillation · 2015Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeComplex fractionated atrial electrograms (CFAEs) and high dominant frequency sites during atrial fibrillation (AF-HDF) are related to the maintenance of atrial fibrillation (AF). HDF sites in sinus rhythm (SR-HDF; as defined by frequencies of >70 Hz) are suggested to be abnormal atrial tissue. Relations between these electrophysiologic signals have not been elucidated.
methodsWe investigated the relations between SR-HDF and CFAE and AF-HDF sites during AF. NavX-based maps of CFAE and left atrium (LA)/pulmonary vein (PV) dominant frequency (DF) during AF and DF maps during SR were created for 23 patients with AF (paroxysmal AF (PAF), n = 14; persistent AF (PerAF), n = 9).
resultsThe extent of overlap between SR-HDF and CFAE sites was 51 ± 18 % (as calculated by the LA/PV segments containing both an SR-HDF site and a CFAE site/total LA/PV segments containing an CFAE site) and the extent of overlap between SR-HDF and AF-HDF sites was 50 ± 35 % (P = 0.7464). However, statistically poor agreement was noted for both (kappa values, 0.07 ± 0.19 and 0.08 ± 0.24, P = 0.8794). The extent of overlap did not differ between PAF and PerAF patients (SR-HDF and CFAE, 52 % (interquartile range (IQR), 42-59) versus 57 % (IQR, 33-67), P = 0.5842; SR-HDF and AF-HDF, 43 % (IQR, 25-85) versus 55 % (IQR, 13-83), P = 0.9465). The bipolar voltage amplitudes of SR-HDF, CFAE, and AF-HDF sites revealed normal voltage areas (1.6 mV (IQR, 0.8-2.7), 1.9 mV (IQR, 1.1-2.8), and 1.5 mV (IQR, 1.7-2.7), respectively).
conclusionsIn both PAF and PerAF, most CFAE and AF-HDF sites did not correspond to the SR-HDF sites or low-voltage area during SR. Thus, most CFAE and DF signals during AF represent functional electrical activities rather than structural remodeling of the atria.
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