ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2013
Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02496962 (Protective Effect of Statin on Arrhythmia and Heart Rate Variability in Healthy People With 48 Hours of Sleep Deprivation), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protective Effect of Statin on Arrhythmia and Heart Rate Variability in Healthy People With 48 Hours of Sleep Deprivation
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of Statin on Arrhythmia and Heart Rate Variability in Healthy Persons With 48-Hour Sleep Deprivation.Journal of the American Heart Association · 2016Trial
- Holter study of heart rate variability in children and adolescents with long QT syndrome.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Acute combined effects of concurrent physical activities on autonomic nervous activation during cognitive tasks.Frontiers in physiology · 2024Article
- Heart rate and heart rate variability following sleep deprivation in retired night shift workers and retired day workers.Psychophysiology · 2023Article
- Long-Term Sleep Deprivation-Induced Myocardial Remodeling and Mitochondrial Dysfunction in Mice Were Attenuated by Lipoic Acid andPharmaceuticals (Basel, Switzerland) · 2022Article
- Effects of 24-h acute total sleep deprivation on physiological coupling in healthy young adults.Frontiers in neuroscience · 2022Article
- The Acute Readiness Monitoring Scale: Assessing Predictive and Concurrent Validation.Frontiers in psychology · 2021Article
- Effect of Ling-Gui-Zhu-Gan decoction major components on the plasma protein binding of metoprolol using UPLC analysis coupled with ultrafiltration.RSC advances · 2018Article
- Decreases in heart rate variability are associated with postoperative complications in hip fracture patients.PloS one · 2017Article
- Sleep Disruption is Associated with Increased Ventricular Ectopy and Cardiac Arrest in Hospitalized Adults.Sleep · 2016Article
- Genetic, Epigenetic, and Environmental Factors Influencing Neurovisceral Integration of Cardiovascular Modulation: Focus on Multiple Sclerosis.Neuromolecular medicine · 2016Review
- Evaluation of remifentanil anesthesia for off-pump coronary artery bypass grafting surgery using heart rate variability.Experimental and therapeutic medicine · 2013Article
- Physiological and autonomic stress responses after prolonged sleep restriction and subsequent recovery sleep in healthy young men.Sleep and biological rhythmsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSleep deprivation, which is a strong stressor, can greatly affect the cardiovascular system of rescue workers. This study aimed to investigate the effect of 24-h sleep deprivation on heart rate variability (HRV) in young healthy people and the protective effect of metoprolol on arrhythmia.
methodsSixty young, healthy subjects (6 women and 54 men), aged 25 ± 4.5 years, were enrolled in this study. All participants received 24-h continuous ambulatory electrocardiogram monitoring. Arrhythmia, time, and frequency domain parameters were analyzed in subjects at the following three stages: normal sleep stage, sleep deprivation stage, and metoprolol treatment before sleep deprivation stage.
resultsAfter 24-h sleep deprivation, the high frequency (HF) of HRV was significantly decreased (p < 0.05), low frequency (LF) was remarkably increased (p < 0.05), and LF/HF was significantly increased compared with those in normal sleep (p < 0.05). Some subjects presented with mild palpitation due to premature atrial complexes and premature ventricular complexes. At the metoprolol treatment stage, compared with the sleep deprivation stage, LF and LF/HF were significantly reduced, HF of HRV was elevated (p < 0.05), and the total amount of premature atrial and ventricular complexes was decreased.
conclusionThe underlying mechanism of arrhythmia and HRV alteration after 24-h sleep deprivation could be attributable to lower vagal activity and elevated sympathetic activity. Metoprolol improves the change in autonomic nervous system activity after 24-h sleep deprivation, which may be responsible for its protective role on arrhythmia in healthy subjects undergoing sleep deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.