ArticleEndocrine2013
F18-FDG-PET/CT thyroid incidentalomas: a wide retrospective analysis in three Italian centres on the significance of focal uptake and SUV value.
Article in Endocrine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Focal Thyroid Incidentalomas onFrontiers in endocrinology · 2021Pooled it
- Risk of malignancy in focal thyroid lesions identified by (18)F-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography: evidence from a large series of studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Prevalence and clinical significance of incidental F18-FDG breast uptake: a systematic review and meta-analysis.Japanese journal of radiology · 2014Pooled it
- Diagnostic performance of (99m)Tc-MIBI scan in predicting the malignancy of thyroid nodules: a meta-analysis.Endocrine · 2013Pooled it
- Definitions of Incidental [Diagnostics (Basel, Switzerland) · 2024Review
- Retrospective analysis of thyroid incidentalomas detected by [Endocrine · 2024Article
- Prevalence of Brain Incidental Lesions Detected byMedicina (Kaunas, Lithuania) · 2022Article
- Retrospective analysis of PSMA PET/CT thyroid incidental uptake in adults: incidence, diagnosis, and treatment/outcome in a tertiary cancer referral center and University Medical Center.European journal of nuclear medicine and molecular imaging · 2022Article
- Radiomics Analysis of [Diagnostics (Basel, Switzerland) · 2022Review
- Long-Term Follow-Up of Thyroid Incidentalomas Visualized with 18F-Fluorodeoxyglucose Positron Emission Tomography-Impact of Thyroid Scintigraphy in the Diagnostic Work-Up.Diagnostics (Basel, Switzerland) · 2021Article
- F18-choline/C11-choline PET/CT thyroid incidentalomas.Endocrine · 2019Review
- Hounsfield unit value has null effect on thyroid nodules at 18F-FDG PET/CT scans.Archives of endocrinology and metabolism · 2018Article
- The Frequency of Focal Thyroid Incidental Findings and Risk of Malignancy Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography in an Iodine Deficient Population.Diagnostics (Basel, Switzerland) · 2018Article
- Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hürthle cell neoplasm.International journal of clinical and experimental pathology · 2018Article
- Adrenocortical Oncocytic Carcinoma and Papillary Thyroid Carcinoma Incidentally Detected in an Asymptomatic Patient by F-18 FDG PET/CT.Asia Oceania journal of nuclear medicine & biology · 2018Article
- Nuclear Molecular and Theranostic Imaging for Differentiated Thyroid Cancer.Molecular imaging and radionuclide therapy · 2017Article
- Article
- Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis.Disease markers · 2017Article
- A prospective cohort study to assess the role of FDG-PET in differentiating benign and malignant follicular neoplasms.Annals of medicine and surgery (2012) · 2016Article
- Comparison of F-18 FDG-PET/CT and Tc-99m MIBI in the preoperative evaluation of cold thyroid nodules in the same patient group.Endocrine · 2015Article
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9 authors.
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Abstract
Thyroid incidental uptake is defined as a thyroid uptake incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for non-thyroid diseases. Aim of the study was to establish the prevalence and pathological nature of focal thyroid incidentalomas detected at F18-FDG-PET/CT in patients studied for oncological purposes and not for thyroid disease. Secondary end point was to establish a possible maximum standardised uptake value cut-off over which a malignant lesion should be suspected. We have retrospectively evaluated 49519 patients who underwent F18-FDG-PET/CT for oncologic purposes in three Nuclear Medicine Centres (N.1 = 11278, N.2 = 31076, N.3 = 7165). A focal incidental thyroid uptake was diagnosed in 729 (1.5 %) patients (287-39.4 % male and 442-60.6 % female; average age: 65.26). Of 729 thyroid incidentalomas 211 (28.9 %) underwent further investigation to determine the nature of the nodule; 124/211 (58.8 %) incidentalomas were benign, 72/211 (34.1 %) malignant, 4/211 (1.9 %) non-diagnostic at cytological examination in the absence of surgery and histological evaluation and 11/211 (5.2 %) were indeterminate at cytological examination. A centre-based receiver operating curve (ROC) analysis of the patients with a definitive diagnosis was performed to identify a SUVmax cut-off useful in differentiating benign from malignant incidentalomas. In the centre N.1 it was 4.8 (sensitivity = 95.7 %, specificity = 46.4 %, area under the curve = 0.758); 5.3 in the centre N.2 (sensitivity = 76.3 %, specificity = 72.5 %, area under the curve = 0.815); 7 in the centre N.3 (sensitivity = 57.1 %, specificity = 79.3 %, area under the curve = 0.627). F18-FDG-PET/CT thyroid incidentalomas are a relevant diagnostic reality which requires further investigations and clinical management especially considering that, despite mainly benign, approximately one third of focal thyroid uptakes are malignant.
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