ReviewDevelopment genes and evolution2013
Stem cell dynamics in Cnidaria: are there unifying principles?
Review in Development genes and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Single-cell analyses of tissue regeneration in two true jellyfish.Molecular biology and evolution · 2026Article
- Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair.Science advances · 2026Article
- Regression of juvenile tentacles is driven by loss of cell proliferation inbioRxiv : the preprint server for biology · 2026Article
- Investigating the evolution and features of regeneration using cnidarians.Integrative and comparative biology · 2025Review
- The property of larval cells of the scleractinian coral, Acropora tenuis, deduced from in vitro cultured cells.Development, growth & differentiation · 2025Article
- A whole-body atlas of BMP signaling activity in an adult sea anemone.BMC biology · 2025Article
- Candidate stem cell isolation and transplantation in Hexacorallia.Cell reports · 2024Article
- Article
- Annelids as models of germ cell and gonad regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Fluorescence In Situ Hybridization as a Tool for Studying the Specification and Differentiation of Cell Types in Nematostella vectensis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle.PLoS biology · 2023Article
- MRI Tracking of Marine Proliferating Cells In Vivo Using Anti-Oct4 Antibody-Conjugated Iron Nanoparticles for Precision in Regenerative Medicine.Biosensors · 2023Article
- A chromosome-scale epigenetic map of theGenome research · 2023Article
- Mutations in coral soma and sperm imply lifelong stem cell renewal and cell lineage selection.Proceedings. Biological sciences · 2023Article
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- Harnessing the Power of Model Organisms To Unravel Microbial Functions in the Coral Holobiont.Microbiology and molecular biology reviews : MMBR · 2022Review
- Cellular adaptations leading to coral fragment attachment on artificial substrates in Acropora millepora (Am-CAM).Scientific reports · 2022Article
- Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inheritance of somatic mutations by animal offspring.Science advances · 2022Article
- Sirtuin Evolution at the Dawn of Animal Life.Molecular biology and evolution · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The study of stem cells in cnidarians has a history spanning hundreds of years, but it has primarily focused on the hydrozoan genus Hydra. While Hydra has a number of self-renewing cell types that act much like stem cells--in particular the interstitial cell line--finding cellular homologues outside of the Hydrozoa has been complicated by the morphological simplicity of stem cells and inconclusive gene expression data. In non-hydrozoan cnidarians, an enigmatic cell type known as the amoebocyte might play a similar role to interstitial cells, but there is little evidence that I-cells and amoebocytes are homologous. Instead, self-renewal and transdifferentiation of epithelial cells was probably more important to ancestral cnidarian development than any undifferentiated cell lineage, and only later in evolution did one or more cell types come under the regulation of a "stem" cell line. Ultimately, this hypothesis and competing ones will need to be tested by expanding genetic and developmental studies on a variety of cnidarian model systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.