ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Assessment of cardiac autonomic neuronal function using PET imaging.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- The sympathetic nervous system in heart failure with preserved ejection fraction.Heart failure reviews · 2025Review
- Cardiovascular positron emission tomography: established and emerging role in cardiovascular diseases.Heart failure reviews · 2023Review
- CardiacPharmaceuticals (Basel, Switzerland) · 2022Review
- Does quantification of [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- The right stuff? Imaging cardiac sympathetic neuronal integrity of the right ventricle in pulmonary arterial hypertension.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Expanding the clinical potential of cardiac radionuclide adrenergic imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.Circulation research · 2020Review
- Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Radiopharmaceutical tracers for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- I-123 metaiodobenzylguanidine innervation imaging as a tool for norepinephrine transporter research: A possible application for genetic analysis in heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Medicinal research reviews · 2018Review
- Neuro-cardiac imaging has a proven value in patient management: Con.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- PET-CMR in heart failure - synergistic or redundant imaging?Heart failure reviews · 2017Review
- SPECT and PET in ischemic heart failure.Heart failure reviews · 2017Review
- Predicting cardiac events using ventricular dyssynchrony in patients who received implantable cardioverter defibrillators: Are more treatment options required?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Cardiac sympathetic activity in chronic heart failure: cardiacNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Review
- Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology.Diagnostics (Basel, Switzerland) · 2016Review
- It's not all in the numbers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Principles and techniques of imaging in identifying the substrate of ventricular arrhythmia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autonomic nervous system is the primary extrinsic control of cardiac performance, and altered autonomic activity has been recognized as an important factor in the progression of various cardiac pathologies. Molecular imaging techniques have been developed for global and regional interrogation of pre- and postsynaptic targets of the cardiac autonomic nervous system. Building on established work with the guanethidine analogue ¹²³I-metaiodobenzylguanidine (MIBG) for single-photon emission tomography (SPECT), development of radiotracers and protocols for positron emission tomography (PET) investigation of autonomic signaling has expanded. PET is limited in availability and requires specialized centers for radiosynthesis and interpretation, but the higher resolution allows for improved regional analysis and kinetic modeling provides more true quantification than is possible with SPECT. A wider array of radiolabeled catecholamines, analogues of catecholamines, and receptor ligands have been characterized and evaluated. Sympathetic neuronal PET tracers have shown promise in the identification of several cardiac pathologies. In particular, recent studies have elucidated a mechanistic role for heterogeneous sympathetic innervation in the development of lethal ventricular arrhythmias. Evaluation of cardiomyocyte adrenergic receptor expression and the parasympathetic nervous system has been slower to develop, with clinical studies beginning to emerge. This review summarizes the clinical and the experimental PET tracers currently available for autonomic imaging and discusses their application in health and cardiovascular disease, with particular emphasis on the major findings of the last decade.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.