ArticleClinical and experimental immunology1990
Depressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis.
Article in Clinical and experimental immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Knockdown of sodium channel NaLaboratory investigation; a journal of technical methods and pathology · 2020Article
- A type 2 response in lipopolysaccharide (LPS)-stimulated whole blood cell cultures from periodontitis patients.Clinical and experimental immunology · 2002Article
- Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.The Journal of clinical investigation · 1998Article
- Enhanced prostaglandin E2 production by monocytes in atopic dermatitis (AD) is not accompanied by enhanced production of IL-6, IL-10 or IL-12.Clinical and experimental immunology · 1998Article
- Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway.Immunology · 1997Article
- Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.The Journal of experimental medicine · 1995Article
- Augmentation of antigen-specific lymphoproliferative responses in vitro by biological response modifiers.Clinical and experimental immunology · 1994Article
- cAMP activates the generation of reactive oxygen species and inhibits the secretion of IL-6 in peripheral blood mononuclear cells from type 2 diabetic patients.Oxidative medicine and cellular longevityArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown that peripheral blood mononuclear cells (PBMC) from patients with atopic dermatitis have a reduced in vitro proliferative responsiveness to concanavalin A when compared with non-atopic controls. Addition of the cyclo-oxygenase inhibitor indomethacin caused a significant enhancement of the mitogen response in the patients, indicating a suppressive effect of cyclooxygenase products. We have further demonstrated increased levels of prostaglandin E2 in the supernatants of the PBMC cultures and increased levels of IgE immune complexes in the sera of the atopic dermatitis patients and therefore hypothesize that IgE immune complexes may cause increased monocyte production of prostaglandins which in turn appears to be responsible for a reduced lymphocyte proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.