ArticleIntensive care medicine2013
Transient decrease in PaCO(2) and asymmetric chest wall dynamics in early progressing pneumothorax.
Article in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Monitoring the respiratory rate by miniature motion sensors in premature infants: a comparative study.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Chest dynamics asymmetry facilitates earlier detection of pneumothorax.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients.Intensive care medicine · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDiagnosis of pneumothorax (PTX) in newborn infants has been reported as late. To explore diagnostic indices for early detection of progressing PTX, and offer explanations for delayed diagnoses.
methodsProgressing PTX was created in rabbits (2.3 ± 0.5 kg, n = 7) by injecting 1 ml/min of air into the pleural space. Hemodynamic parameters, tidal volume, EtCO(2), SpO(2), blood gas analyses and chest wall tidal displacements (TDi) on both sides of the chest were recorded.
results(Mean ± SD): A decrease in SpO(2) below 90 % was detected only after 46.6 ± 11.3 min in six experiments. In contrary to the expected gradual increase of CO(2), there was a prolonged transient decrease of 14.2 ± 4.5 % in EtCO(2) (p < 0.01), and a similar decrease in PaCO(2) (p < 0.025). EtCO(2) returned back to baseline only after 55.2 ± 24.7 min, and continued to rise thereafter. The decrease in CO(2) was a mirror image of the 14.6 ± 5.3 % increase in tidal volume. The analysis of endotracheal flow and pressure dynamics revealed a paradoxical transient increase in the apparent compliance. Significant decrease in mean arterial blood pressure was observed after 46.2 ± 40.1 min. TDi provided the most sensitive and earliest sign of PTX, decreasing on the PTX side after 16.1 ± 7.2 min. The TDi progressively decreased faster and lower on the PTX side, thus enabling detection of asymmetric ventilation.
conclusionsThe counterintuitive transient prolonged decrease in CO(2) without changes in SpO(2) may explain the delay in diagnosis of PTX encountered in the clinical environment. An earlier indication of asymmetrically decreased ventilation on the affected side was achieved by monitoring the TDi.
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