Evidence map›Paper›PMID 23179316›Full record

ArticleJournal of natural medicines2013

Saw palmetto ethanol extract inhibits adipocyte differentiation.

Nicole Villaverde, Adriana Galvis, Adriana Marcano, Horacio A Priestap, Bradley C Bennett, M Alejandro Barbieri

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicole VillaverdeDepartment of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Adriana Galvis
Adriana Marcano
Horacio A Priestap
Bradley C Bennett
M Alejandro Barbieri
Florida International University · USFairchild Tropical Botanic Garden · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fruits of saw palmetto have been used for the treatment of a variety of urinary and reproductive system problems. In this study we investigated whether the fruit extracts affect in vitro adipogenesis. Saw palmetto ethanol extract inhibited the lipid droplet accumulation by induction media in a dose-dependent manner, and it also attenuated the protein expressions of C-EBPα and PPARγ. Phosphorylation of Erk1/2 and Akt1 were also decreased by saw palmetto ethanol extract. This report suggests that saw palmetto extracts selectively affect the adipocyte differentiation through the modulation of several key factors that play a critical role during adipogenesis.

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAnimalsCCAAT-Enhancer-Binding ProteinsDose-Response Relationship, DrugEthanolFruitMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationPhytotherapyPlant ExtractsPlants, MedicinalPPAR gammaAkt1 protein, mouseCCAAT-Enhancer-Binding ProteinsCEBPA protein, mouseEthanolMapk1 protein, mouseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Plant ExtractsPPAR gammaProto-Oncogene Proteins c-aktsaw palmetto extractSolvents

Identifiers

PMID23179316
OpenAlexW1965041135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.