ArticleClinical orthopaedics and related research2013
Emerging ideas: Engineering the periosteum: revitalizing allografts by mimicking autograft healing.
Article in Clinical orthopaedics and related research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies.Exploration (Beijing, China) · 2025Review
- From Free Tissue Transfer to Hydrogels: A Brief Review of the Application of the Periosteum in Bone Regeneration.Gels (Basel, Switzerland) · 2023Review
- Biomimicking design of artificial periosteum for promoting bone healing.Journal of orthopaedic translation · 2022Review
- Mechanical strain induces ex vivo expansion of periosteum.PloS one · 2022Article
- Biomimetic three-layered membranes comprising (poly)-ε-caprolactone, collagen and mineralized collagen for guided bone regeneration.Regenerative biomaterials · 2021Article
- Review
- Vascularized Periosteal Flaps Accelerate Osteointegration and Revascularization of Allografts in Rats.Clinical orthopaedics and related research · 2019Article
- Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure.Journal of biomedical materials research. Part A · 2018Article
- [Research progress of the role of periosteum in distraction osteogenesis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Review
- Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions.Journal of biomedical materials research. Part A · 2017Article
- Encapsulation of primary salivary gland cells in enzymatically degradable poly(ethylene glycol) hydrogels promotes acinar cell characteristics.Acta biomaterialia · 2017Article
- Extracellular Matrix Revisited: Roles in Tissue Engineering.International neurourology journal · 2016Review
- Emulating native periosteum cell population and subsequent paracrine factor production to promote tissue engineered periosteum-mediated allograft healing.Biomaterials · 2015Article
- Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications.Tissue engineering. Part A · 2015Article
- Engineering clinically relevant volumes of vascularized bone.Journal of cellular and molecular medicine · 2015Review
- Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds.Tissue engineering. Part A · 2015Article
- Myoconductive and osteoinductive free-standing polysaccharide membranes.Acta biomaterialia · 2015Article
- Degradable hydrogels for spatiotemporal control of mesenchymal stem cells localized at decellularized bone allografts.Acta biomaterialia · 2014Article
- Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge.World journal of stem cells · 2014Review
- The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing.Biomaterials · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundTo fulfill the need for large volumes, devitalized allografts are used to treat massive bone defects despite a 60%, 10-year postimplantation fracture rate. Allograft healing is inferior to autografts where the periosteum orchestrates remodeling. HYPOTHESIS: By augmenting allografts with a tissue engineered periosteum consisting of tunable and degradable, poly(ethylene glycol) (PEG) hydrogels for mesenchymal stem cell (MSC) transplantation, the functions critical for periosteum-mediated healing will be identified and emulated. METHOD OF STUDY: PEG hydrogels will be designed to emulate periosteum-mediated autograft healing to revitalize allografts. We will exploit murine femoral defect models for these approaches. Critical-sized, 5-mm segmental defects will be created and filled with decellularized allograft controls or live autograft controls. Alternatively, defects will be treated with our experimental approaches: decellularized allografts coated with MSCs transplanted via degradable PEG hydrogels to mimic progenitor cell densities and persistence during autograft healing. Healing will be evaluated for 9 weeks using microcomputed tomography, mechanical testing, and histologic analysis. If promising, MSC densities, hydrogel compositions, and genetic methods will be used to isolate critical aspects of engineered periosteum that modulate healing. Finally, hydrogel biochemical characteristics will be altered to initiate MSC and/or host-material interactions to further promote remodeling of allografts. SIGNIFICANCE: This approach represents a novel tissue engineering strategy whereby degradable, synthetic hydrogels will be exploited to emulate the periosteum. The microenvironment, which will mediate MSC transplantation, will use tunable PEG hydrogels for isolation of critical allograft revitalization factors. In addition, hydrogels will be modified with biochemical cues to further augment allografts to reduce or eliminate revision surgeries associated with allograft failures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.