ArticleLab on a chip2013
Ultra-localized single cell electroporation using silicon nanowires.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Microfluidic Electroporation: Recent Advances and Applications.Advances in experimental medicine and biology · 2026Review
- In Situ Electroporation on PERFECT Filter for High-Efficiency and High-Viability Tumor Cell Labeling.Micromachines · 2022Article
- Towards high throughput and high information coverage: advanced single-cell mass spectrometric techniques.Analytical and bioanalytical chemistry · 2022Review
- Microfluidic Based Physical Approaches towards Single-Cell Intracellular Delivery and Analysis.Micromachines · 2021Review
- Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells.Nature communications · 2021Article
- Review of Microfluidic Methods for Cellular Lysis.Micromachines · 2021Review
- Methods and platforms for analysis of nucleic acids from single-cell based on microfluidics.Microfluidics and nanofluidics · 2021Review
- High Throughput and Highly Controllable Methods for In Vitro Intracellular Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2020Review
- Internalization and Viability Studies of Suspended Nanowire Silicon Chips in HeLa Cells.Nanomaterials (Basel, Switzerland) · 2020Article
- Single-cell individualized electroporation with real-time impedance monitoring using a microelectrode array chip.Microsystems & nanoengineering · 2020Article
- Cell lysis via acoustically oscillating sharp edges.Lab on a chip · 2019Article
- Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy.Trends in analytical chemistry : TRAC · 2019Article
- Microfluidic reactors for advancing the MS analysis of fast biological responses.Microsystems & nanoengineering · 2019Article
- Localized Single-Cell Lysis and Manipulation Using Optothermally-Induced Bubbles.Micromachines · 2017Article
- Electroporation on microchips: the harmful effects of pH changes and scaling down.Scientific reports · 2015Article
- Article
- Microfluidic electroporation for cellular analysis and delivery.Lab on a chip · 2013Review
- Ultralocalized thermal reactions in subnanoliter droplets-in-air.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
Analysis of cell-to-cell variation can further the understanding of intracellular processes and the role of individual cell function within a larger cell population. The ability to precisely lyse single cells can be used to release cellular components to resolve cellular heterogeneity that might be obscured when whole populations are examined. We report a method to position and lyse individual cells on silicon nanowire and nanoribbon biological field effect transistors. In this study, HT-29 cancer cells were positioned on top of transistors by manipulating magnetic beads using external magnetic fields. Ultra-rapid cell lysis was subsequently performed by applying 600-900 mV(pp) at 10 MHz for as little as 2 ms across the transistor channel and the bulk substrate. We show that the fringing electric field at the device surface disrupts the cell membrane, leading to lysis from irreversible electroporation. This methodology allows rapid and simple single cell lysis and analysis with potential applications in medical diagnostics, proteome analysis and developmental biology studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.