Trial reportContemporary clinical trials2013
Aerobic training reduces systemic oxidative stress in young women with elevated levels of F2-isoprostanes.
Trial report in Contemporary clinical trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pooled it
- Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review.BioMed research international · 2021Pooled it
- The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review.Obesity facts · 2017Pooled it
- Plasma FThe Journal of nutrition · 2017Trial
- Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal Women: A Randomized Controlled Trial.Cancer prevention research (Philadelphia, Pa.) · 2016Trial
- Exercise at lunchtime: effect on glycemic control and oxidative stress in middle-aged men with type 2 diabetes.European journal of applied physiology · 2016Trial
- Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.Fertility and sterility · 2015Trial
- No effect of caloric restriction or exercise on radiation repair capacity.Medicine and science in sports and exercise · 2015Trial
- Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial.The Journal of physiology · 2014Trial
- Intracellular Oxidative Stress Induced by Physical Exercise in Adults: Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- Targeting Oxidative Stress Involved in Endometriosis and Its Pain.Biomolecules · 2022Review
- Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining.Antioxidants (Basel, Switzerland) · 2019Review
- Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Effects of exercise on markers of oxidative stress: an Ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial.BMJ open sport & exercise medicine · 2016Article
- Consumption of a high glycemic load but not a high glycemic index diet is marginally associated with oxidative stress in young women.Nutrition research (New York, N.Y.) · 2015Article
- Longitudinal determinants of energy levels in knowledge workers.Journal of occupational and environmental medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The purpose of this trial was to determine whether exercise without weight loss would reduce F2-isoprostanes in previously sedentary young women. Participants (N=319) were randomized to four months of 150min/week aerobic exercise or a control group. Plasma free F2-isoprostanes were measured by gas chromatography-mass spectrometry. Other assessments included fitness and % body fat. Intervention groups were compared with stratification by quartiles of baseline plasma F2-isoprostane. This stratified comparison was linearly adjusted for baseline plasma F2-isoprostane and we also used baseline plasma F2-isoprostane as a propensity score to balance the intervention. Training resulted in significant improvements in aerobic fitness (0.88 METs) and body fat percent (1%) in exercisers compared to controls (p<0.001). The exercise group had significantly higher mean baseline plasma F2-isoprostanes (79.1 vs 67.9pg/mL) than the control group in the highest quartile of baseline plasma F2-isoprostanes. Within this highest quartile, exercise led to a greater decline in plasma F2-isoprostanes (-20.2±2.5pg/mL) than control (-7.4±2.5pg/mL); with adjustment for baseline plasma F2-isoprostanes and in the balanced groups, this difference was reduced but remained significant. Four months of exercise training resulted in significant reductions of systemic oxidative stress only among previously sedentary young women who were in the highest quartile of plasma F2-isoprostanes at baseline (≥57pg/mL). Our findings indicate that the benefits of aerobic exercise in reducing systemic oxidative stress may be limited to those who present higher baseline levels of plasma F2-isoprostanes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.