Evidence map›Paper›PMID 23178720›Full record

ArticleFEBS letters2013

Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587.

Bior K Bior, Bryan A Ballif

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bior K BiorDepartment of Biology, University of Vermont, Burlington, VT 05405, USA.
Bryan A Ballif
University of Vermont · US

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
VOLATILE SIGNALING IN PHARBITIS NILP20RR016462 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI KIRSHENBAUM, ARI PHILLIP · 2001 to 2011
$31.1M
Proteomics Core for Neuroscience P20 RR16435P20RR016435 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI SPEES, JEFFREY L · 2001 to 2010
$23.5M
Center for Neuroscience ExcellenceP30GM103498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI PARSONS, RODNEY L · 2012 to 2015
$4.3M
NCRR NIH HHS 5 P20 RR016435NCRR NIH HHS P20 RR016435NCRR NIH HHS P20 RR016462NCRR NIH HHS P20 RR16462NIGMS NIH HHS P20 GM103449NIGMS NIH HHS P30 GM103498
6 · The paper itself

Abstract

Crk and CrkL adaptors play essential neuronal positioning roles downstream of Reelin-induced Dab1 tyrosine phosphorylation. Recently we identified Cin85 to be a CrkL-SH3 binding partner from embryonic murine brain while others found Cin85 binds directly to Dab1. Here using mass spectrometry, biochemical and mutational analyses we show that Dab1 suppresses Cin85 phosphorylation at Ser587. Furthermore a Cin85 Ser587 phosphomimetic disrupts the Dab1-Cin85 complex without affecting the Cin85-CapZ complex. These data provide an early glimpse into how Cin85 phosphorylation might alter the composition of its scaffolding partners to regulate its diverse roles including vesicular trafficking, receptor endocytosis and actin remodeling.

Indexed as

Down-RegulationAdaptor Proteins, Signal TransducingAnimalsCapZ Actin Capping ProteinCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsHEK293 CellsHumansImmunoprecipitationMiceMutagenesis, Site-DirectedMutant ProteinsNeoplasm ProteinsNerve Tissue ProteinsNeuronsPhosphorylationAdaptor Proteins, Signal TransducingCapza1 protein, mouseCapZ Actin Capping ProteinCell Adhesion Molecules, NeuronalDab1 protein, mouseExtracellular Matrix ProteinsMutant ProteinsNeoplasm ProteinsNerve Tissue ProteinsRecombinant Fusion ProteinsReelin ProteinRELN protein, humanReln protein, mouseSerineSerine EndopeptidasesSh3kbp1 protein, mouse

Identifiers

PMID23178720
PMCPMC3532509
OpenAlexW2040670485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.