Evidence map›Paper›PMID 23178704›Full record

ReviewBiotechnology advances

Enabling stem cell therapies for tissue repair: current and future challenges.

Victor W Wong, Michael Sorkin, Geoffrey C Gurtner

Abstract readReview
In one paragraph

Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. A Mini-Review on Fibroblast-Derived Exosomes as Wound Healing Stimulators.International journal of hematology-oncology and stem cell research · 2025
    Review
  3. Review
  4. Review
  5. Skin immunity in wound healing and cancer.Frontiers in immunology · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victor W WongDepartment of Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305, USA.
Michael Sorkin
Geoffrey C Gurtner

Funding

Reversal of Progenitor Cell Deficits in DiabetesR01DK074095 · NIDDK · UNIVERSITY OF ARIZONA · PI GURTNER, GEOFFREY C · 2005 to 2025
$6.4M
Targeting HIF-1 alpha Dysfunction in Complications of AgingR01AG025016 · NIA · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C · 2004 to 2015
$3.5M
Inside-Out Tissue Engineering for Organ FabricationR01EB005718 · NIBIB · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2010 to 2013
$1.4M
NIA NIH HHS R01 AG025016NIA NIH HHS R01-AG025016NIBIB NIH HHS R01 EB005718NIBIB NIH HHS R01-EB005718NIDDK NIH HHS R01 DK074095NIDDK NIH HHS R01-DK074095
6 · The paper itself

Abstract

Stem cells embody the tremendous potential of the human body to develop, grow, and repair throughout life. Understanding the biologic mechanisms that underlie stem cell-mediated tissue regeneration is key to harnessing this potential. Recent advances in molecular biology, genetic engineering, and material science have broadened our understanding of stem cells and helped bring them closer to widespread clinical application. Specifically, innovative approaches to optimize how stem cells are identified, isolated, grown, and utilized will help translate these advances into effective clinical therapies. Although there is growing interest in stem cells worldwide, this enthusiasm must be tempered by the fact that these treatments remain for the most part clinically unproven. Future challenges include refining the therapeutic manipulation of stem cells, validating these technologies in randomized clinical trials, and regulating the global expansion of regenerative stem cell therapies.

Indexed as

AnimalsBiotechnologyHumansRegenerative MedicineStem CellsStem Cell TransplantationTissue Engineering

Identifiers

PMID23178704
PMCPMC3620919

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.