Evidence map›Paper›PMID 23178589›Full record

ArticleVirus research2013

Evaluation of the genetic diversity of avian paramyxovirus type 4.

Baibaswata Nayak, Shreeraj Nayak, Anandan Paldurai, Sachin Kumar, Roberta De Nardi, Calogero Terregino, Peter L Collins, Siba K Samal

Open access · greenAbstract read
In one paragraph

Article in Virus research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Limited evidence of intercontinental dispersal of avian paramyxovirus serotype 4 by migratory birds.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Baibaswata NayakVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Shreeraj Nayak
Anandan Paldurai
Sachin Kumar
Roberta De Nardi
Calogero Terregino
Peter L Collins
Siba K Samal
Virginia–Maryland College of Veterinary Medicine · USIstituto Zooprofilattico Sperimentale delle Venezie · ITNational Institute of Allergy and Infectious Diseases · USUniversity of Maryland, College Park · US

Funding

Paramyxoviruses as Vaccine Vectors Against Highly Pathogenic VirusesZIAAI000938 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BUCHHOLZ, URSULA · 2009 to 2025
$12.4M
Newcastle disease virus vectored HIV vaccinesR21AI093198 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SAMAL, SIBA K · 2012 to 2013
$411k
Intramural NIH HHSNIAID NIH HHS R21 AI093198PHS HHS N01A060009
6 · The paper itself

Abstract

Avian paramyxoviruses (APMVs) belong to the genus Avulavirus in the family Paramyxoviridae and include at least nine serotypes, APMV-1 to -9, as well as two additional provisional serotypes. Newcastle disease virus (NDV), which comprises APMV-1, is the most extensively studied APMV because it is an important poultry pathogen. A moderate level of antigenic and genetic diversity is recognized for APMV-1 isolates, but our knowledge of the antigenic and genetic diversity of the other APMV serotypes is limited. APMV-4 is frequently isolated from waterfowl around the world. To date complete genome sequences of APMV-4 are available for only strains, which were isolated from ducks in Hong Kong, Korea and Belgium over a period of 37 years. We have carried out genome sequencing from the nucleocapsid (N) gene-end signal to the polymerase (L) gene-start signal of five APMV-4 strains recently isolated from Italy. Each of the eight APMV-4 strains has the same F protein cleavage site, DIQPR↓F. They also share a high level of nucleotide and amino acid sequence identity: for example, the F and HN glycoproteins have greater than 97% sequence identity between the various strains. Thus, comparison of these eight strains of APMV-4 did not provide evidence of substantial diversity, in contrast to similar studies with APMV-2, -3, and -6, in which the F and HN glycoproteins exhibited up to 20-30% amino acid sequence variation within a subgroup. Reciprocal cross-HI assay using post infection chicken sera also failed to detect significant antigenic variation among the available APMV-4 strains.

Indexed as

Genetic VariationAnimalsAvulavirusBase SequenceCell LineChick EmbryoChickensGene OrderGenome, ViralMolecular Sequence DataPhosphoproteinsPhylogenySequence AlignmentSequence Analysis, DNASerotypingViral ProteinsPhosphoproteinsViral Proteins

Identifiers

PMID23178589
PMCPMC3557600
OpenAlexW2053744590

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.