ArticleNeuroImage2013
Improved in vivo diffusion tensor imaging of human cervical spinal cord.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 87 citations in OpenAlex.
- Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness.Scientific reports · 2026Article
- Spinal cord involvement and cardiovascular autonomic dysfunction in Parkinson's disease.Scientific reports · 2026Article
- Quantitative evaluation of cervical muscles in patients with degenerative cervical myelopathy using diffusion tensor imaging metrics.Bone & joint research · 2026Article
- Diffusion tractography outside the brain: the road less travelled.Brain structure & function · 2026Review
- Comparing single-shot EPI and 2D-navigated, multi-shot EPI diffusion tensor imaging acquisitions in the lumbar spinal cord at 3T.Magnetic resonance imaging · 2025Article
- Test-Retest Reliability and Inter-Scanner Reproducibility of Improved Spinal Diffusion Tensor Imaging.Diagnostics (Basel, Switzerland) · 2025Article
- Characterization of neurite and soma organization in the brain and spinal cord with diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Tract-specific spinal damage in SCA2, SCA3 and SCA6.Journal of neurology · 2024Article
- Influence of preprocessing, distortion correction and cardiac triggering on the quality of diffusion MR images of spinal cord.Magnetic resonance imaging · 2024Article
- Effectiveness of regional diffusion MRI measures in distinguishing multiple sclerosis abnormalities within the cervical spinal cord.Brain and behavior · 2023Article
- Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury.Annals of clinical and translational neurology · 2023Article
- Diffusion basis spectrum imaging predicts long-term clinical outcomes following surgery in cervical spondylotic myelopathy.The spine journal : official journal of the North American Spine Society · 2023Article
- Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy.Frontiers in neuroscience · 2023Article
- Diffusion-weighted MRI of the spinal cord in cervical spondylotic myelopathy after instrumented fusion.Frontiers in neurology · 2023Article
- Analysis of combined clinical and diffusion basis spectrum imaging metrics to predict the outcome of chronic cervical spondylotic myelopathy following cervical decompression surgery.Journal of neurosurgery. Spine · 2022Article
- Diffusion Kurtosis Imaging of Neonatal Spinal Cord in Clinical Routine.Frontiers in radiology · 2022Article
- Spinal cord magnetic resonance imaging and spectroscopy detect early-stage alterations and disease progression in Friedreich ataxia.Brain communications · 2022Article
- Generic acquisition protocol for quantitative MRI of the spinal cord.Nature protocols · 2021Article
- Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.Scientific data · 2021Article
- Non-local means based Rician noise filtering for diffusion tensor and kurtosis imaging in human brain and spinal cord.BMC medical imaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We describe a cardiac gated high in-plane resolution axial human cervical spinal cord diffusion tensor imaging (DTI) protocol. Multiple steps were taken to optimize both image acquisition and image processing. The former includes slice-by-slice cardiac triggering and individually tiltable slices. The latter includes (i) iterative 2D retrospective motion correction, (ii) image intensity outlier detection to minimize the influence of physiological noise, (iii) a non-linear DTI estimation procedure incorporating non-negative eigenvalue priors, and (iv) tract-specific region-of-interest (ROI) identification based on an objective geometry reference. Using these strategies in combination, radial diffusivity (λ(⊥)) was reproducibly measured in white matter (WM) tracts (adjusted mean [95% confidence interval]=0.25 [0.22, 0.29] μm(2)/ms), lower than previously reported λ(⊥) values in the in vivo human spinal cord DTI literature. Radial diffusivity and fractional anisotropy (FA) measured in WM varied from rostral to caudal as did mean translational motion, likely reflecting respiratory motion effect. Given the considerable sensitivity of DTI measurements to motion artifact, we believe outlier detection is indispensable in spinal cord diffusion imaging. We also recommend using a mixed-effects model to account for systematic measurement bias depending on cord segment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.