Evidence map›Paper›PMID 23178421›Full record

SynthesisThe Journal of infection2013

Aspergillus meningitis: a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases.

Spinello Antinori, Mario Corbellino, Luca Meroni, Federico Resta, Salvatore Sollima, Massimo Tonolini, Anna Maria Tortorano, Laura Milazzo, Lorenzo Bello, Elisa Furfaro and 2 more

Abstract readCase ReportsSystematic Review
In one paragraph

Synthesis in The Journal of infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  7. Article
  8. Aneurysm, meningitis, and subarachnoid hemorrhage secondary to intracranialQuantitative imaging in medicine and surgery · 2024
    Article
  9. Review
  10. Case reports in infectious diseases · 2024
    Article
  11. Article
  12. Review
  13. Current medical mycology · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Spinello AntinoriDepartment of Biomedical and Clinical Sciences Luigi Sacco, Università di Milano, Milano, Italy. spinello.antinori@unimi.it
Mario Corbellino
Luca Meroni
Federico Resta
Salvatore Sollima
Massimo Tonolini
Anna Maria Tortorano
Laura Milazzo
Lorenzo Bello
Elisa Furfaro
Massimo Galli
Claudio Viscoli

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe the pathogenesis, clinical presentation, cerebrospinal fluid findings and outcome of Aspergillus meningitis, meningoencephalitis and arachnoiditis.

methodsA case of Aspergillus meningitis is described. A comprehensive review of the English-language literature was conducted to identify all reported cases of Aspergillus meningitis described between January 1973 and December 2011.

resultsNinety-three cases (including the one described herein) of Aspergillus meningitis were identified. Fifty-two (55.9%) were in individuals without any predisposing factor or known causes of immunosuppression. Acute and chronic meningitis was diagnosed in 65.6% of patients and meningoencephalitis in 24.7% of them with the remaining presenting with spinal arachnoiditis and ventriculitis. Cerebrospinal fluid cultures for Aspergillus spp. were positive in about 31% of cases and the galactomannan antigen test in 87%. Diagnosis during life was achieved in 52 patients (55.9%) with a case fatality rate of 50%. The overall case fatality rate was 72.1%.

conclusionsAspergillus meningitis may occur in both immunocompetent and immunocompromised patients and run an acute or chronic course. The findings of this systematic review extend the information on this life-threatening infection and could assist physicians in achieving an improved outcome.

Indexed as

AdultAspergillosisAspergillus flavusCentral Nervous SystemCerebrospinal FluidFemaleHumansImmunocompromised HostMaleMeningitis, Fungal

Identifiers

PMID23178421
PMCPMC7112586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.