ArticleDevelopmental and comparative immunology2013
Caudal is a negative regulator of the Anopheles IMD pathway that controls resistance to Plasmodium falciparum infection.
Article in Developmental and comparative immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
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- Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023Review
- Bacterial communities of Aedes aegypti mosquitoes differ between crop and midgut tissues.PLoS neglected tropical diseases · 2023Article
- Differential Expression of Immune Genes in thePathogens (Basel, Switzerland) · 2022Article
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- C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites.PLoS biology · 2022Article
- Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH.Cell reports · 2021Article
- Larval Diet Abundance Influences Size and Composition of the Midgut Microbiota ofFrontiers in microbiology · 2021Article
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- Glucose transporter GLUT1 influences Plasmodium berghei infection in Anopheles stephensi.Parasites & vectors · 2020Article
- Vector biology meets disease control: using basic research to fight vector-borne diseases.Nature microbiology · 2019Review
- PGRP-LD mediates A. stephensi vector competency by regulating homeostasis of microbiota-induced peritrophic matrix synthesis.PLoS pathogens · 2018Article
- Amino acid metabolic signaling influences Aedes aegypti midgut microbiome variability.PLoS neglected tropical diseases · 2017Article
- Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microbiota-induced peritrophic matrix regulates midgut homeostasis and prevents systemic infection of malaria vector mosquitoes.PLoS pathogens · 2017Article
- Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
Malaria parasite transmission depends upon the successful development of Plasmodium in its Anopheles mosquito vector. The mosquito's innate immune system constitutes a major bottleneck for parasite population growth. We show here that in Anopheles gambiae, the midgut-specific transcription factor Caudal acts as a negative regulator in the Imd pathway-mediated immune response against the human malaria parasite Plasmodium falciparum. Caudal also modulates the mosquito midgut bacterial flora. RNAi-mediated silencing of Caudal enhanced the mosquito's resistance to bacterial infections and increased the transcriptional abundance of key immune effector genes. Interestingly, Caudal's silencing resulted in an increased lifespan of the mosquito, while it impaired reproductive fitness with respect to egg laying and hatching.
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