ReviewBrain research2013
Optogenetic identification of striatal projection neuron subtypes during in vivo recordings.
Review in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed.
- Is continuous dopaminergic delivery still a major goal to be achieved in the treatment of Parkinson's disease?Journal of Parkinson's disease · 2026Review
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Automated device for permitting free movement during simultaneous photometry and electrophysiology in mice.Nature methods · 2026Article
- Neurobehavioral deficits, oxidative dysregulation, and inflammatory responses in male Swiss mice following sub-acute exposure to ethanol extract of Leiotrametes lactinea Berk.BMC neuroscience · 2026Article
- The striatal indirect pathway mediates hesitation.Nature neuroscience · 2026Article
- Aberrant striatal firing mediates impulsive decision-making in a mouse model of Parkinson's disease.Brain : a journal of neurology · 2026Article
- Gastrin-releasing peptide signaling in the nucleus accumbens medial shell regulates neuronal excitability and motivation.Nature communications · 2025Article
- Article
- In-vivo properties and functional subtypes of gonadotropin-releasing hormone neurons.iScience · 2025Article
- In vivo cell-type and brain region classification via multimodal contrastive learning.bioRxiv : the preprint server for biology · 2025Article
- Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits.bioRxiv : the preprint server for biology · 2025Article
- Formation of an auditory sensory representation in posterior striatum emerges during a brief temporal window of associative learning in normal and hearing-impaired gerbils.Frontiers in systems neuroscience · 2025Article
- Circadian Rhythms in Conditioned Threat Extinction Reflect Time-of-Day Differences in Ventromedial Prefrontal Cortex Neural Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input.Cell reports · 2024Article
- Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency.Nature neuroscience · 2024Article
- Multifunctional Fiber-Based Optoacoustic Emitter as a Bidirectional Brain Interface.Advanced healthcare materials · 2023Article
- Polydimethylsiloxane as a more biocompatible alternative to glass in optogenetics.Scientific reports · 2023Article
- The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression.Neuron · 2023Article
- Article
- Unraveling the dynamics of dopamine release and its actions on target cells.Trends in neurosciences · 2023Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Optogenetics has revolutionized neuroscience over the past several years by allowing researchers to modulate the activity of specific cell types, both in vitro and in vivo. One promising application of optogenetics is to use channelrhodopsin-2 (ChR2) mediated spiking to identify distinct cell types in electrophysiological recordings from awake behaving animals. In this paper, we apply this approach to in vivo recordings of the two major projection cell types in the striatum: the direct- and indirect-pathway medium spiny neurons. We expressed ChR2 in the neurons of the direct or indirect pathways using a cre-dependent viral strategy and performed electrical recordings together with optical stimulation using an implanted microwire array that included an integrated optical fiber. Despite the apparent simplicity of identifying ChR2-expressing neurons as those that respond to light, we encountered multiple potential confounds when applying this approach. Here, we describe and address these confounds and provide a Matlab tool so that others can implement our analysis methods. This article is part of a Special Issue entitled Optogenetics (7th BRES).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.