Trial reportJournal of voice : official journal of the Voice Foundation2012
Vocal exercise may attenuate acute vocal fold inflammation.
Trial report in Journal of voice : official journal of the Voice Foundation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Pre- and post-operative voice therapy (PaPOV): Development of an intervention for patients with benign vocal fold lesions.International journal of language & communication disorders · 2023Pooled it
- The impact and application exercises on vocal fatigue.Scientific reports · 2026Trial
- An open phase I/IIa study evaluating safety, patient-reported outcomes and voice function after surgery, local administration of mesenchymal stromal cells and voice training in patients with vocal fold scarring and dysphonia.Stem cell research & therapy · 2026Trial
- Rehabilitation Treatment Specification System: Reliability and Dosage of Common Ingredients in Standard-of-Care Therapy for Vocal Hyperfunction.American journal of speech-language pathology · 2026Article
- Psychometric and Acoustic Investigation of Identity and Phonotraumatic Vocal Hyperfunction.Journal of voice : official journal of the Voice Foundation · 2026Article
- Multi-timescale finite element modeling of vocal fold edema progression due to phonotrauma.The Journal of the Acoustical Society of America · 2026Article
- Voice Outcomes in Patients With Laryngopharyngeal Reflux: A Systematic Review and Meta-Analysis.Cureus · 2025Review
- Pre- and Postoperative Voice Therapy for Benign Vocal Fold Lesions: An International Electronic Delphi Consensus Study.Journal of voice : official journal of the Voice Foundation · 2025Article
- Biophysical aspects of mechanotransduction in cells and their physiological/biological implications in vocal fold vibration: a narrative review.Frontiers in cell and developmental biology · 2025Review
- Mechanotransduction in the Vocal Fold Microenvironment: A Narrative Review.Journal of speech, language, and hearing research : JSLHR · 2024Review
- Acoustic Effects of Vocal Warm-Up: A 7-Week Longitudinal Case Study.Journal of voice : official journal of the Voice Foundation · 2024Article
- The influence of source-filter interaction on the voice source in a three-dimensional computational model of voice production.The Journal of the Acoustical Society of America · 2023Article
- Acoustic Description ofIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Office-Based Structural Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis.Journal of clinical medicine · 2022Article
- Voice rest after vocal fold polyp surgery: A Swedish register study of 588 patients.Laryngoscope investigative otolaryngology · 2022Article
- Bioreactors for Vocal Fold Tissue Engineering.Tissue engineering. Part B, Reviews · 2022Review
- The effects of vocal exertion on lung volume measurements and acoustics in speakers reporting high and low vocal fatigue.PloS one · 2022Article
- Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications.Frontiers in medicine · 2022Review
- Distribution and Appearance of Ki-67, IL-1α, IL-10, and PGP 9.5 in Reinke's Oedema-Affected Larynx Tissue Compared with Control Tissue.Life (Basel, Switzerland) · 2021Article
- Mitigating the Effects of Acute Vocal Exertion in Individuals With Vocal Fatigue.The Laryngoscope · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
objectives/hypothesesThe objective was to assess the utility of selected "resonant voice" (RV) exercises for the reduction of acute vocal fold inflammation. The hypothesis was that relatively large-amplitude, low-impact vocal fold exercises associated with RV would reduce inflammation more than spontaneous speech (SS) and possibly more than voice rest. STUDY
designThe study design was prospective, randomized, and double blind.
methodsNine vocally healthy adults underwent a 1-hour vocal loading procedure, followed by randomization to a SS condition, vocal rest condition, or RV exercise condition. Treatments were monitored in clinic for 4 hours and continued extraclinically until the next morning. At baseline (BL), immediately after loading, after the 4-hour in-clinic treatment, and 24 hours post-BL, secretions were suctioned from the vocal folds bilaterally and submitted to enzyme-linked immunosorbent assay to estimate concentrations of key markers of tissue injury and inflammation: interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor α, matrix metalloproteinase (MMP)-8, and IL-10.
resultsComplete data sets were obtained for three markers--IL-1β, IL-6, and MMP-8--for one subject in each treatment condition. For these markers, results were poorest at 24-hour follow-up in the SS condition, sharply improved in the voice rest condition, and was the best in the RV condition. Average results for all markers and responsive subjects with normal BL mediator concentrations revealed an almost identical pattern.
conclusionsSome forms of tissue mobilization may be useful to attenuate acute vocal fold inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.