ArticleThe American journal of medicine2013
Respiratory impairment in older persons: when less means more.
Article in The American journal of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations.Journal of the American Geriatrics Society · 2016Trial
- Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons.Journal of the American Geriatrics Society · 2014Trial
- Article
- GPs should not try to detect mild COPD.NPJ primary care respiratory medicine · 2020Article
- FEVRespiratory care · 2020Article
- Re-evaluation of combination therapy in chronic obstructive pulmonary disease (COPD).Respiratory medicine · 2019Article
- Article
- The Global Lung Function Initiative (GLI) Network: bringing the world's respiratory reference values together.Breathe (Sheffield, England) · 2017Review
- Spirometry, Static Lung Volumes, and Diffusing Capacity.Respiratory care · 2017Article
- Asthma-COPD overlap syndrome in the US: a prospective population-based analysis of patient-reported outcomes and health care utilization.International journal of chronic obstructive pulmonary disease · 2017Article
- Phenotype of Spirometric Impairment in an Aging Population.American journal of respiratory and critical care medicine · 2016Article
- Review
- Phenotype of normal spirometry in an aging population.American journal of respiratory and critical care medicine · 2015Article
- Comment on: Wollmer P, Engström G. Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV1/VC: An outcome study. Respiratory Medicine (2013) 107, 1460-1462.: Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV1/VC.Respiratory medicine · 2015Article
- Short-term prognostic value of forced expiratory volume in 1 second divided by height cubed in a prospective cohort of people 80 years and older.BMC geriatrics · 2015Article
- Respiratory symptoms, spirometric respiratory impairment, and respiratory disease in middle-aged and older persons.Journal of the American Geriatrics Society · 2015Article
- Ethnic differences in respiratory impairment.Thorax · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAmong older persons, within the clinical context of respiratory symptoms and mobility, evidence suggests that improvements are warranted regarding the current approach for identifying respiratory impairment (ie, a reduction in pulmonary function).
methodsAmong 3583 white participants aged 65 to 80 years (Cardiovascular Health Study), we calculated the prevalence of respiratory impairment using the current spirometric standard from the Global Initiative for Obstructive Lung Disease (GOLD) and an alternative spirometric approach termed "lambda-mu-sigma" (LMS). Results for GOLD- and LMS-defined respiratory impairment were evaluated for their (cross-sectional) association with respiratory symptoms and gait speed, and for the 5-year cumulative incidence probability of mobility disability.
resultsThe prevalence of respiratory impairment was 49.7% (1780/3583) when using the GOLD and 23.2% (831/3583) when using LMS. Differences in prevalence were most evident among participants who had no respiratory symptoms, with respiratory impairment classified more often by the GOLD (38.1% [326/855]) than LMS (12.3% [105/855]), as well as among participants who had normal gait speed, with respiratory impairment classified more often by the GOLD (46.4% [1003/2164]) than LMS (19.3% [417/2164]). Conversely, the 5-year cumulative incidence probability of mobility disability for respiratory impairment was higher for LMS than GOLD (0.313 and 0.249 for never-smokers, and 0.352 and 0.289 for ever-smokers, respectively), but was similar for normal spirometry by LMS or GOLD (0.193 and 0.185 for never-smokers, and 0.219 and 0.216 for ever-smokers, respectively).
conclusionsAmong older persons, the LMS approach (vs the GOLD approach) classifies respiratory impairment less frequently in those who are asymptomatic and is more strongly associated with mobility disability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.